{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:34:52Z","timestamp":1790228092074,"version":"4.1.0"},"reference-count":43,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":5814,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Non-adherence with antidepressant treatment is very common. Increasing adherence to pharmacological treatment may affect response rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To review and summarise quantitative evidence on factors associated with adherence and of adherence-enhancing interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A systematic review of computerised databases was carried out to identify quantitative studies of adherence in depression. Papers retained addressed unipolar depression and considered adherence as the primary end-point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of studies published between 1973 and 1999, 32 met the review criteria: epidemiological descriptive studies (<jats:italic>n<\/jats:italic>=14): non-random comparisons of control and intervention groups (<jats:italic>n<\/jats:italic>=3); randomised interventions (<jats:italic>n<\/jats:italic>=14); and meta-analysis (<jats:italic>n<\/jats:italic>=1). Patient education and medication clinics were the interventions most commonly tested, combined with a variety of other interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The studies did not give consistent indications of which interventions may be effective. Carefully designed clinical trials are needed to clarify the effect of single and combined interventions.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.180.2.104","type":"journal-article","created":{"date-parts":[[2002,8,29]],"date-time":"2002-08-29T21:36:18Z","timestamp":1030656978000},"page":"104-109","source":"Crossref","is-referenced-by-count":204,"title":["Patient adherence in the treatment of depression"],"prefix":"10.1192","volume":"180","author":[{"given":"S.","family":"Pampallona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bollini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tibaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kupelnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Munizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000270803_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1981.tb00751.x"},{"key":"S0007125000270803_ref43","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6394(1997)6:1<10::AID-DA2>3.0.CO;2-9"},{"key":"S0007125000270803_ref22","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830100072009"},{"key":"S0007125000270803_ref42","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18233"},{"key":"S0007125000270803_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)01073-2"},{"key":"S0007125000270803_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.12.1128"},{"key":"S0007125000270803_ref5","first-page":"187","volume-title":"Patient Compliance in Medical Practice and Clinical Trials","author":"Engstrom","year":"1991"},{"key":"S0007125000270803_ref18","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1177\/070674378002500807","article-title":"Effect of patient education on medication compliance","volume":"25","author":"Seltzer","year":"1980","journal-title":"Canadian Journal of Psychiatry"},{"key":"S0007125000270803_ref2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/070674378503000203","article-title":"Compliance to referrals from the psychiatric emergency room","volume":"30","author":"Blouin","year":"1985","journal-title":"Canadian Journal of Psychiatry"},{"key":"S0007125000270803_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1974.01760150063009"},{"key":"S0007125000270803_ref1","first-page":"1138","volume":"36","author":"Roter","year":"1998","journal-title":"Effectiveness of interventions to improve patient compliance. 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