{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:42:09Z","timestamp":1791160929883,"version":"4.1.0"},"reference-count":15,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":5664,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Antipsychotic drugs are associated with sexual dysfunction but the mechanisms are poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To ascertain the frequency of sexual dysfunction in patients taking conventional antipsychotics and to determine the possible underlying mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sexual dysfunction was assessed in 101 patients receiving conventional antipsychotic medication, 57 normal controls and 55 controls attending a sexual dysfunction clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sexual dysfunction occurred in 45% of patients taking antipsychotic medication, 17% of normal controls and 61% of controls attending a sexual dysfunction clinic. Sexual dysfunction was associated with autonomic side-effects in normoprolactinaemic males, but the presence of hyperprolactinaemia overrode other causes of sexual dysfunction. For women, hyperprolactinaemia was the main cause of sexual dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Conventional antipsychotic medications cause significant levels of sexual dysfunction. Clinicians should routinely enquire about sexual symptoms prior to the prescription of antipsychotics and on follow-up.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.181.1.49","type":"journal-article","created":{"date-parts":[[2002,8,29]],"date-time":"2002-08-29T21:36:18Z","timestamp":1030656978000},"page":"49-55","source":"Crossref","is-referenced-by-count":200,"title":["Sexual dysfunction in patients taking conventional antipsychotic medication"],"prefix":"10.1192","volume":"181","author":[{"given":"Shubulade","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"O'Keane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000161525_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)91164-9"},{"key":"S0007125000161525_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(92)90003-N"},{"key":"S0007125000161525_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(95)80386-6"},{"key":"S0007125000161525_ref2","first-page":"137","article-title":"Sexual dysfunction in male schizophrenic patients","volume":"56","author":"Aizenberg","year":"1995","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0007125000161525_ref4","first-page":"645","article-title":"Effect of antipsychotic drugs on reproductive functions","volume":"27","author":"Blair","year":"1966","journal-title":"Diseases of the Nervous System"},{"key":"S0007125000161525_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700036539"},{"key":"S0007125000161525_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-198208000-00004"},{"key":"S0007125000161525_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1987.tb10566.x"},{"key":"S0007125000161525_ref11","first-page":"40","volume-title":"Annual Abstract of Statistics","author":"Wisniewski","year":"1999"},{"key":"S0007125000161525_ref13","first-page":"240","article-title":"Schizophrenia, oligospermia, and the phenothiazines","volume":"28","author":"Shader","year":"1967","journal-title":"Diseases of the Nervous System"},{"key":"S0007125000161525_ref14","doi-asserted-by":"publisher","DOI":"10.1192\/pb.24.5.172"},{"key":"S0007125000161525_ref9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1176\/ajp.133.1.82","article-title":"Thioridazine and sexual dysfunction","volume":"133","author":"Kotin","year":"1976","journal-title":"American Journal of Psychiatry"},{"key":"S0007125000161525_ref3","first-page":"16","article-title":"Influence of menopause on sexuality","volume":"40","author":"Bachmann","year":"1995","journal-title":"International Journal of Fertility and Menopausal Studies"},{"key":"S0007125000161525_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-440X(96)90052-8"},{"key":"S0007125000161525_ref15","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979596"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000161525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:54:23Z","timestamp":1557190463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000161525\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["S0007125000161525"],"URL":"https:\/\/doi.org\/10.1192\/bjp.181.1.49","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}