{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T03:26:07Z","timestamp":1764905167321},"reference-count":31,"publisher":"Royal College of Psychiatrists","issue":"S43","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":5602,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The risk for schizophrenia has been associated with a family history of this and other psychiatric disorders. The relationship between age at first contact and family history of psychiatric illness is not certain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To estimate the risks for schizophrenia associated with a range of psychiatric diagnoses in family members and to investigate the relationship between these risks and age at first contact for schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A nested case\u2013control study design was employed. Psychiatric admission data and socio-economic data were available for 7704 cases admitted between 1981 and 1998 in Denmark, 192 590 gender- and age-matched controls, and for the parents and siblings of all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Controlling for socio-economic factors, risk for schizophrenia was associated with a family history of all psychiatric disorders except substance misuse and independently with a family history of suicide. The risk for schizophrenia associated with a family history of psychiatric disorders decreased as age at first contact increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Risk for schizophrenia is associated with a range of psychiatric disorders in family members and these risks are not constant across the risk period.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.181.43.s19","type":"journal-article","created":{"date-parts":[[2002,10,29]],"date-time":"2002-10-29T15:03:57Z","timestamp":1035903837000},"page":"s19-s25","source":"Crossref","is-referenced-by-count":39,"title":["Family history of psychiatric disorders and age at first contact in schizophrenia: An epidemiological study"],"prefix":"10.1192","volume":"181","author":[{"given":"Majella","family":"Byrne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esben","family":"Agerbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preben Bo","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S000712500002852X_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1999.tb00990.x"},{"key":"S000712500002852X_ref31","volume-title":"The ICD\u201310 Classification of Mental and Behavioural Disorders. 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