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The recent introduction of prolactin-sparing antipsychotic agents makes a re-examination of this problem timely.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To review the literature on antipsychotic-induced hyperprolactinaemia and its consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A search was made of the Medline database (1966\u20132002) for key articles, supplemented by cross-referencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During antipsychotic treatment prolactin concentrations can rise to ten times normal levels or above, and existing data indicate that 17\u201378% of female patients have amenorrhoea with or without galactorrhoea. Survey data, however, suggest that clinicians underestimate the prevalence of these conditions. Long-term consequences of antipsychotic-related hypo-oestrogenism require further research but are likely to include premature bone loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antipsychotic-induced hyperprolactinaemia should become a focus of interest in the drug treatment of psychiatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.182.3.199","type":"journal-article","created":{"date-parts":[[2003,2,28]],"date-time":"2003-02-28T20:22:44Z","timestamp":1046463764000},"page":"199-204","source":"Crossref","is-referenced-by-count":127,"title":["Antipsychotic-induced hyperprolactinaemia in women: pathophysiology, severity and consequences"],"prefix":"10.1192","volume":"182","author":[{"given":"A.","family":"Wieck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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