{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:52:49Z","timestamp":1771023169335,"version":"3.50.1"},"reference-count":22,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":4994,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Membrane phospholipid and high-energy abnormalities measured with phosphorus magnetic resonance spectroscopy (<jats:sup>31<\/jats:sup>P-MRS) have been reported in patients with schizophrenia in several brain regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Using improved imaging techniques, previously inaccessible brain regions were examined in patients with first-episode schizophrenia and healthy volunteers with 4.0 T <jats:sup>31<\/jats:sup>P-MRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Brain spectra were collected <jats:italic>in vivo<\/jats:italic> from 15 patients with first-episode schizophrenia and 15 healthy volunteers from 15 cm<jats:sup>3<\/jats:sup> effective voxels in the thalamus, cerebellum, hippocampus, anterior\/posterior cingulate, prefrontal cortex and parieto-occipital cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>People with first-episode schizophrenia showed increased levels of glycerophosphocholine in the anterior cingulate. Inorganic phosphate, phosphocreatine and adenosine triphosphate concentrations were also increased in the anterior cingulate in this group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The increased phosphodiester and high-energy phosphate levels in the anterior cingulate of brains of people with first-episode schizophrenia may indicate neural overactivity in this region during the early stages of the illness, resulting in increased excitotoxic neural membrane breakdown.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.184.5.409","type":"journal-article","created":{"date-parts":[[2004,5,3]],"date-time":"2004-05-03T19:13:11Z","timestamp":1083611591000},"page":"409-415","source":"Crossref","is-referenced-by-count":46,"title":["Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia"],"prefix":"10.1192","volume":"184","author":[{"given":"J. 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