{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:53:01Z","timestamp":1774608781942,"version":"3.50.1"},"reference-count":25,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":4933,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Helsinki High-Risk Study follows up all women born between 1916 and 1948 and treated for schizophrenia-spectrum disorders in psychiatric hospitals in Helsinki, their offspring born between 1960 and 1964, and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the cumulative incidence of adulthood Axis I disorders among offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Using all hospital and out-patient treatment records we rediagnosed parents and offspring according to DSM\u2013 IV-TR criteria. Offspring were grouped by mother's diagnosis (schizophrenia <jats:italic>n<\/jats:italic> = 104, schizoaffective disorder <jats:italic>n<\/jats:italic>=20, other schizophrenia-spectrum disorder <jats:italic>n<\/jats:italic>=30, and affective disorder <jats:italic>n<\/jats:italic>=25) and compared with a control group (<jats:italic>n<\/jats:italic> = 176). The cumulative incidences of Axis I disorders among offspring were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative incidences of any psychotic disorder were 13.5%, 10.0%, 10.0%, 4.0% and 1.1% among offspring of mothers with schizophrenia, schizo-affective disorder, other schizophrenia-spectrum disorders, affective disorders and controls, respectively. The corresponding figures for schizophrenia were 6.7%, 5.0%, 6.7%, 0% and 0.6%, and for any mental disorder 23.1%, 20.0%, 20.0%, 12.0% and 6.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Offspring of mothers with a psychotic disorder have heightened risk of developing a wide range of severe mental disorders.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.185.1.11","type":"journal-article","created":{"date-parts":[[2004,6,30]],"date-time":"2004-06-30T21:58:06Z","timestamp":1088632686000},"page":"11-17","source":"Crossref","is-referenced-by-count":50,"title":["Cumulative incidence of mental disorders among offspring of mothers with psychotic disorder"],"prefix":"10.1192","volume":"185","author":[{"given":"Laura T.","family":"Niemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaana 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