{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:19:44Z","timestamp":1789460384943,"version":"build-2803163510"},"reference-count":20,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":4718,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Helsinki High-Risk Study monitors women treated for schizophrenia-spectrum disorders in Helsinki mental hospitals before 1975, their offspring, and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the development of high-risk and control group children, and investigate which factors predicted future psychiatric disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We examined information from childhood and school health record cards of 159 high-risk and 99 control group offspring. Logistic regression was used to assess whether developmental abnormalities predicted later mental disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with controls, children in the high-risk group had more emotional symptoms before school age, attentional problems and social inhibition at school age, and neurological soft signs throughout. Inthisgroup pre-school socia adjustment problems (OR=9.7, 95% CI 1.8\u201351.8) or severe neurological symptom: (Fisher's test, <jats:italic>P<\/jats:italic>=0.006) predicted future schizophrenia-spectrum disorder. Social adjustment problems and emotional symptoms during school age predicted future non-psychotic psychiatric disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study supports the validity of neurological, emotional, social and behavioural markers as vulnerability indicators of psychotic and other mental disorders, particularly among children genetically at high risk of psychosis.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.186.2.108","type":"journal-article","created":{"date-parts":[[2005,1,31]],"date-time":"2005-01-31T18:33:31Z","timestamp":1107196411000},"page":"108-114","source":"Crossref","is-referenced-by-count":76,"title":["Childhood predictors of future psychiatric morbidity in offspring of mothers with psychotic disorder"],"prefix":"10.1192","volume":"186","author":[{"given":"Laura T.","family":"Niemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana M.","family":"Suvisaari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari K.","family":"Haukka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouko K.","family":"L\u00f6nnqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S000712500023064X_ref18","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579402001025"},{"key":"S000712500023064X_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.5.449"},{"key":"S000712500023064X_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579402001104"},{"key":"S000712500023064X_ref13","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.100.4.674"},{"key":"S000712500023064X_ref12","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2003.64.745"},{"key":"S000712500023064X_ref6","volume-title":"Schizophrenia Genesis: The Origin of Madness","author":"Gottesman","year":"1991"},{"key":"S000712500023064X_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830110071009"},{"key":"S000712500023064X_ref2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.5.420"},{"key":"S000712500023064X_ref5","volume-title":"Classification of Socio-Economic Groups","year":"1989"},{"key":"S000712500023064X_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00234-7"},{"key":"S000712500023064X_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830190049005"},{"key":"S000712500023064X_ref10","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.158.5.615"},{"key":"S000712500023064X_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(03)00099-9"},{"key":"S000712500023064X_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820210041005"},{"key":"S000712500023064X_ref19","doi-asserted-by":"publisher","DOI":"10.3109\/00048678409161295"},{"key":"S000712500023064X_ref8","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026425304480"},{"key":"S000712500023064X_ref1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2000"},{"key":"S000712500023064X_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.3.215"},{"key":"S000712500023064X_ref11","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1080\/j.1440-1614.2003.01263.x","article-title":"Temperament, childhood environment and psychopathology as risk factors for avoidant and borderline personality disorders","volume":"37","author":"Joyce","year":"2003","journal-title":"Australian and New Zealand Journal of Psychiatry"},{"key":"S000712500023064X_ref16","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.185.1.11"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S000712500023064X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T14:22:51Z","timestamp":1557152571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S000712500023064X\/type\/journal_article"}},"subtitle":["Results from the Helsinki High-Risk Study"],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S000712500023064X"],"URL":"https:\/\/doi.org\/10.1192\/bjp.186.2.108","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}