{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:44:05Z","timestamp":1780109045728,"version":"3.54.0"},"reference-count":32,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":4598,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Irritable bowel syndrome often leads to impaired functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the contribution of psychiatric disorders to impaired outcome in severe irritable bowel syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with severe irritable bowel syndrome entering a psychological treatment trial (<jats:italic>n<\/jats:italic>=257) were interviewed using the Schedules for Clinical Assessment in Neuropsychiatry. Outcomes were number of days of restricted activity, role limitation (physical) score of the Short Form Health Survey and costs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, depressive disorder (29% of patients), panic (12%) and neurasthenia (35%) were associated with impairment; number of psychiatric disorders was associated in a dose\u2013response fashion (<jats:italic>P<\/jats:italic>=0. 005). At follow-up, depressive disorder and neurasthenia were associated with role limitation score. Improved depression was associated with improved role functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Depressive, panic and neurasthenic disorders contribute to poor outcomes in severe irritable bowel syndrome, and appropriate treatment should be available to these patients.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.186.6.507","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T02:38:53Z","timestamp":1117593533000},"page":"507-515","source":"Crossref","is-referenced-by-count":63,"title":["Outcome in severe irritable bowel syndrome with and without accompanying depressive, panic and neurasthenic disorders"],"prefix":"10.1192","volume":"186","author":[{"given":"Francis","family":"Creed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Ratcliffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Rigby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Tomenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth","family":"Guthrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Read","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000166498_ref32","volume-title":"Schedules for Clinical Assessment in Neuropsychiatry (SCAN)","year":"1994"},{"key":"S0007125000166498_ref30","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32392"},{"key":"S0007125000166498_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/BF02071408"},{"key":"S0007125000166498_ref27","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"S0007125000166498_ref26","first-page":"351","volume-title":"Rome II. The Functional Gastrointestinal Disorders: Diagnosis, Pathophysiology and Treatments; A Multinational Consensus","author":"Thompson","year":"2002"},{"key":"S0007125000166498_ref25","first-page":"75","article-title":"Functional bowel disease and functional abdominal pain","volume":"5","author":"Thompson","year":"1992","journal-title":"Gastroenterology International"},{"key":"S0007125000166498_ref22","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950220060012"},{"key":"S0007125000166498_ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6708.1138"},{"key":"S0007125000166498_ref18","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.183.1.5"},{"key":"S0007125000166498_ref17","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200119060-00003"},{"key":"S0007125000166498_ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01290.x"},{"key":"S0007125000166498_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01936.x"},{"key":"S0007125000166498_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02064187"},{"key":"S0007125000166498_ref7","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50055"},{"key":"S0007125000166498_ref6","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.43.4.302"},{"key":"S0007125000166498_ref5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-9_Part_2-200105011-00010"},{"key":"S0007125000166498_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)00126-P"},{"key":"S0007125000166498_ref2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.173.2.123"},{"key":"S0007125000166498_ref19","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008970312068"},{"key":"S0007125000166498_ref31","volume-title":"International Statistical Classification of Diseases and Related Health Problems","year":"1992"},{"key":"S0007125000166498_ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00160.x"},{"key":"S0007125000166498_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00083-2"},{"key":"S0007125000166498_ref23","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750153476"},{"key":"S0007125000166498_ref16","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"S0007125000166498_ref21","first-page":"57","article-title":"Psychosocial moderators of quality of life in irritable bowel syndrome","volume":"583","author":"Naliboff","year":"1998","journal-title":"European Journal of Surgery Supplement"},{"key":"S0007125000166498_ref14","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16484"},{"key":"S0007125000166498_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01977.x"},{"key":"S0007125000166498_ref1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"S0007125000166498_ref28","volume-title":"SF-36 Physical and Mental Health Summary Scales: A User's Manual","author":"Ware","year":"1994"},{"key":"S0007125000166498_ref3","first-page":"163","volume-title":"Measuring Mental Health Needs","author":"Beecham","year":"1992"},{"key":"S0007125000166498_ref10","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.8.1274"},{"key":"S0007125000166498_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810330075011"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000166498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T20:52:33Z","timestamp":1556916753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000166498\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0007125000166498"],"URL":"https:\/\/doi.org\/10.1192\/bjp.186.6.507","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}