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The primary outcome measure was the number of patients in response (550% improvement from baseline in Young Mania Rating Scale score) and receiving therapy at week 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At week 12, significantly more patients taking aripiprazole (49. 7%) were in response and receiving therapy compared with those taking haloperidol (28. 4%; <jats:italic>P<\/jats:italic>&lt;0. 001). Continuation rates differed markedly between treatments (week 12: aripiprazole, 50. 9%; haloperidol, 29. 1%). Extrapyramidal adverse events were more frequent with haloperidol than aripiprazole (62. 7% <jats:italic>v.<\/jats:italic> 24. 0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aripiprazole showed superior levels of response and tolerability to haloperidol in the treatment of an acute manic episode for up to 12 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.187.3.235","type":"journal-article","created":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T20:09:12Z","timestamp":1125518952000},"page":"235-242","source":"Crossref","is-referenced-by-count":137,"title":["Effectiveness of aripiprazole v. 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