{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:44:58Z","timestamp":1787021098948,"version":"build-2736575974"},"reference-count":43,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"unspecified","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec id=\"S000712501700006X_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>22q11.2 deletion syndrome (22q11.2DS) is associated with high rates of neurodevelopmental disorder, however, the links between developmental coordination disorder (DCD), intellectual function and psychiatric disorder remain unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S000712501700006X_sec_a2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To establish the prevalence of indicative DCD in children with 22q11.2DS and examine associations with IQ, neurocognition and psychopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S000712501700006X_sec_a3\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Neurocognitive assessments and psychiatric interviews of 70 children with 22q11.2DS (mean age 11.2, s.d. = 2.2) and 32 control siblings (mean age 11.5, s.d. = 2.1) were carried out in their homes. Nine children with 22q11.2DS and indicative DCD were subsequently assessed in an occupational therapy clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S000712501700006X_sec_a4\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Indicative DCD was found in 57 (81.4%) children with 22q11.2DS compared with 2 (6.3%) control siblings (odds ratio (OR) = 36.7,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). Eight of nine (89%) children with indicative DCD met DSM-5 criteria for DCD. Poorer coordination was associated with increased numbers of anxiety, (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), attention-deficit hyperactivity disorder (ADHD) (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and autism-spectrum disorder (ASD) symptoms (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) in children with 22q11.2DS. Furthermore, 100% of children with 22q11.2DS and ADHD had indicative DCD (20 of 20), as did 90% of children with anxiety disorder (17 of 19) and 96% of children who screened positive for ASD (22 of 23). The Developmental Coordination Disorder Questionnaire score was related to sustained attention (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.006), even after history of epileptic fits (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.006) and heart problems (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.009) was taken into account.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S000712501700006X_sec_a5\" sec-type=\"conclusion\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinicians should be aware of the high risk of coordination difficulties in children with 22q11.2DS and its association with risk of mental disorder and specific neurocognitive deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S000712501700006X_sec_a6\">\n                    <jats:title>Declaration of interest<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2017.6","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T22:08:04Z","timestamp":1515449284000},"page":"27-33","source":"Crossref","is-referenced-by-count":40,"title":["Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome"],"prefix":"10.1192","volume":"212","author":[{"given":"Adam C.","family":"Cunningham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Delport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Cumines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Busse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E. 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