{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:24:37Z","timestamp":1791869077886,"version":"4.3.4"},"reference-count":14,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Prader\u2013Willi syndrome (PWS) is a rare condition because of the deletion of paternal chromosomal material (del PWS), or a maternal uniparental disomy (mUPD PWS), at 15q11-13. Affective psychosis is more prevalent in mUPD PWS. We investigated the relationship between the two PWS genetic variants and brain-stem serotonin transporter (5-HTT) availability in adult humans. Mean brain-stem 5-HTT availability determined by [<jats:sup>123<\/jats:sup>I]-beta-CIT single photon emission tomography was lower in eight adults with mUPD PWS compared with nine adults with del PWS (mean difference \u22120.93, <jats:italic>t<\/jats:italic> = \u22122.85, <jats:italic>P<\/jats:italic> = 0.014). Our findings confirm an association between PWS genotype and brain-stem 5-HTT availability, implicating a maternally expressed\/paternally imprinted gene, that is likely to account for the difference in psychiatric phenotypes between the PWS variants.<\/jats:p><jats:sec id=\"S0007125017000071_sec_a1\"><jats:title>Declaration of interest<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.2017.7","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T03:08:04Z","timestamp":1515467284000},"page":"57-58","source":"Crossref","is-referenced-by-count":7,"title":["Brain-stem serotonin transporter availability in maternal uniparental disomy and deletion Prader\u2013Willi syndrome"],"prefix":"10.1192","volume":"212","author":[{"given":"Rajeev","family":"Krishnadas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally-Ann","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Nicol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Pimlott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"McArthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Cavanagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,4]]},"reference":[{"key":"S0007125017000071_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(04)59006-2"},{"key":"S0007125017000071_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32022"},{"key":"S0007125017000071_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.08.005"},{"key":"S0007125017000071_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30004"},{"key":"S0007125017000071_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07340-3"},{"key":"S0007125017000071_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707002504"},{"key":"S0007125017000071_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.07.034"},{"key":"S0007125017000071_ref11","doi-asserted-by":"publisher","DOI":"10.3390\/diseases3040382"},{"key":"S0007125017000071_ref1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.11.792"},{"key":"S0007125017000071_ref9","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.182.4.347"},{"key":"S0007125017000071_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00519-2"},{"key":"S0007125017000071_ref5","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0212"},{"key":"S0007125017000071_ref7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s007870050062","article-title":"Is monoamine oxidase activity elevated in Prader-Willi syndrome?","volume":"7","author":"Akefeldt","year":"1998","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"S0007125017000071_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107320"}],"container-title":["The British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125017000071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T21:45:49Z","timestamp":1555364749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125017000071\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0007125017000071"],"URL":"https:\/\/doi.org\/10.1192\/bjp.2017.7","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}