{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:56:45Z","timestamp":1793120205563,"version":"4.5.0"},"reference-count":117,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec id=\"S0007125018001447_sec_a1\"><jats:title>Background<\/jats:title><jats:p>A reliable biomarker signature for bipolar disorder sensitive to illness phase would be of considerable clinical benefit. Among circulating blood-derived markers there has been a significant amount of research into inflammatory markers, neurotrophins and oxidative stress markers.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125018001447_sec_a2\"><jats:title>Aims<\/jats:title><jats:p>To synthesise and interpret existing evidence of inflammatory markers, neurotrophins and oxidative stress markers in bipolar disorder focusing on the mood phase of illness.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125018001447_sec_a3\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Following PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analyses) guidelines, a systematic review was conducted for studies investigating peripheral biomarkers in bipolar disorder compared with healthy controls. We searched Medline, Embase, PsycINFO, SciELO and Web of Science, and separated studies by bipolar mood phase (mania, depression and euthymia). Extracted data on each biomarker in separate mood phases were synthesised using random-effects model meta-analyses.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125018001447_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>In total, 53 studies were included, comprising 2467 cases and 2360 controls. Fourteen biomarkers were identified from meta-analyses of three or more studies. No biomarker differentiated mood phase in bipolar disorder individually. Biomarker meta-analyses suggest a combination of high-sensitivity C-reactive protein\/interleukin-6, brain derived neurotrophic factor\/tumour necrosis factor (TNF)-\u03b1 and soluble TNF-\u03b1 receptor 1 can differentiate specific mood phase in bipolar disorder. Several other biomarkers of interest were identified.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125018001447_sec_a5\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Combining biomarker results could differentiate individuals with bipolar disorder from healthy controls and indicate a specific mood-phase signature. Future research should seek to test these combinations of biomarkers in longitudinal studies.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125018001447_sec_a6\"><jats:title>Declaration of interest<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.2018.144","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T10:55:10Z","timestamp":1534416910000},"page":"514-525","source":"Crossref","is-referenced-by-count":189,"title":["Neurotrophins, cytokines, oxidative stress mediators and mood state in bipolar disorder: systematic review and meta-analyses"],"prefix":"10.1192","volume":"213","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0977-0362","authenticated-orcid":false,"given":"Tobias","family":"Rowland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin 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