{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:51:56Z","timestamp":1787593916231,"version":"build-2736575974"},"reference-count":35,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec id=\"S000712501800288X_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Deficits in frontal lobe perfusion have been demonstrated in late-life depression; however, studies to date have generally involved small numbers, used neuroimaging rather than bedside testing and have not controlled for important covariates.<\/jats:p><\/jats:sec><jats:sec id=\"S000712501800288X_sec_a2\"><jats:title>Aims<\/jats:title><jats:p>We aimed to examine the association between depressive symptoms and frontal lobe perfusion during standing, in a large cohort of community-dwelling older people.<\/jats:p><\/jats:sec><jats:sec id=\"S000712501800288X_sec_a3\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Participants aged \u226550 years underwent continuous measurement of orthostatic blood pressure by finometry, and frontal lobe perfusion by near-infrared spectroscopy. Depressive symptoms were assessed by the eight-item Centre for Epidemiological Studies Depression Scale. Real-time frontal lobe cerebral oxygenation was measured by the Portalite System, detecting changes in frontal lobe perfusion and reporting a tissue saturation index score.<\/jats:p><\/jats:sec><jats:sec id=\"S000712501800288X_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Almost 8% (209 out of 2616) had clinically significant depressive symptoms. Multilevel models demonstrated a significantly lower tissue saturation index in participants with depressive symptoms at both 60 and 90 s post-stand, with coefficients of \u22120.43 (95% CI \u22120.63 to \u22120.22) and \u22120.37 (95% CI \u22120.57 to \u22120.16), respectively. Controlling for relevant covariates did not significantly attenuate these associations. After addition of systolic blood pressure this association was no longer significant, suggesting lower blood pressure may modify this relationship.<\/jats:p><\/jats:sec><jats:sec id=\"S000712501800288X_sec_a5\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that lower frontal lobe perfusion, related to lower values of baseline systolic blood pressure, is associated with clinically significant depressive symptoms in a cohort of community-dwelling older people. Given the recognised longitudinal association between lower blood pressure and depression in older people, this may represent a potential therapeutic target for prevention of incident depression.<\/jats:p><\/jats:sec><jats:sec id=\"S000712501800288X_sec_a6\"><jats:title>Declaration of interest<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.2018.288","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T05:07:01Z","timestamp":1546578421000},"page":"230-236","source":"Crossref","is-referenced-by-count":27,"title":["The association between frontal lobe perfusion and depressive symptoms in later 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