{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:40:36Z","timestamp":1790084436875,"version":"4.0.1"},"reference-count":44,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec id=\"S0007125022001787_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Prior research has solely focused on the association between handgrip strength and risk of depression in single countries or general populations, but more knowledge is required from wider-spread cohorts and target populations.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125022001787_sec_a2\"><jats:title>Aims<\/jats:title><jats:p>This study aimed to investigate the association between handgrip strength and risk of depression using repeated measures in adults aged 50 years and over.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125022001787_sec_a3\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Data on handgrip strength and risk of depression were retrieved from the Survey of Health, Ageing and Retirement in Europe (SHARE) waves 1, 2, 4, 5, 6 and 7, using a hand dynamometer (Smedley, S Dynamometer, TTM) and the EURO-D 12-item scale, respectively. Time-varying exposure and covariates were modelled using both Cox regression and restricted cubic splines.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125022001787_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 115 601 participants (mean age 64.3 years (s.d. = 9.9), 54.3% women) were followed-up for a median of 7.3 years (interquartile range: 3.9\u201311.8) and 792 459 person-years. During this period, 30 208 (26.1%) participants experienced a risk of depression. When modelled as a continuous variable, we observed an inverse significant association for each kg increase of handgrip strength and depression up to 40 kg in men and up to 27 kg in women.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125022001787_sec_a5\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Being physically strong may serve as a preventive factor for depression in older adults, but this is limited up to a maximum specific threshold for men and women.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.2022.178","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T07:58:36Z","timestamp":1670227116000},"page":"135-142","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":37,"title":["Dose\u2013response association of handgrip strength and risk of depression: a longitudinal study of 115 601 older adults from 24 countries"],"prefix":"10.1192","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-3429","authenticated-orcid":false,"given":"Rub\u00e9n","family":"L\u00f3pez-Bueno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-8346","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Calatayud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Louis","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Casa\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"del Pozo Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"S0007125022001787_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.09.036"},{"key":"S0007125022001787_ref38","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.106666"},{"key":"S0007125022001787_ref9","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18094823"},{"key":"S0007125022001787_ref35","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719001454"},{"key":"S0007125022001787_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.01.036"},{"key":"S0007125022001787_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2021.110678"},{"key":"S0007125022001787_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2009.01084.x"},{"key":"S0007125022001787_ref30","first-page":"1","article-title":"Risk factors associated with low handgrip strength in the older Korean population","volume":"14","author":"Kim","year":"2019","journal-title":"PLoS One"},{"key":"S0007125022001787_ref8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-031811-124544"},{"key":"S0007125022001787_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.03.005"},{"key":"S0007125022001787_ref26","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577654"},{"key":"S0007125022001787_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.11.025"},{"key":"S0007125022001787_ref31","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3618"},{"key":"S0007125022001787_ref32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-00751-3"},{"key":"S0007125022001787_ref14","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2019.1699021"},{"key":"S0007125022001787_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-015-0279-7"},{"key":"S0007125022001787_ref34","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S194543"},{"key":"S0007125022001787_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02143-7"},{"key":"S0007125022001787_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt088"},{"key":"S0007125022001787_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afg111"},{"key":"S0007125022001787_ref1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X1304150831123535"},{"key":"S0007125022001787_ref25","unstructured":"25 B\u00f6rsch-Supan, A . 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