{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:27:59Z","timestamp":1772087279456,"version":"3.50.1"},"reference-count":47,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/00639"],"award-info":[{"award-number":["PI14\/00639"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/00918"],"award-info":[{"award-number":["PI14\/00918"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec id=\"S0007125022001921_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Understanding the evolution of negative symptoms in first-episode psychosis (FEP) requires long-term longitudinal study designs that capture the progression of this condition and the associated brain changes.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125022001921_sec_a2\"><jats:title>Aims<\/jats:title><jats:p>To explore the factors underlying negative symptoms and their association with long-term abnormal brain trajectories.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125022001921_sec_a3\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>We followed up 357 people with FEP over a 10-year period. Factor analyses were conducted to explore negative symptom dimensionality. Latent growth mixture modelling (LGMM) was used to identify the latent classes. Analysis of variance (ANOVA) was conducted to investigate developmental trajectories of cortical thickness. Finally, the resulting ANOVA maps were correlated with a wide set of regional molecular profiles derived from public databases.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125022001921_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Three trajectories (stable, decreasing and increasing) were found in each of the three factors (expressivity, experiential and attention) identified by the factor analyses. Patients with an increasing trajectory in the expressivity factor showed cortical thinning in caudal middle frontal, pars triangularis, rostral middle frontal and superior frontal regions from the third to the tenth year after the onset of the psychotic disorder. The <jats:italic>F<\/jats:italic>-statistic map of cortical thickness expressivity differences was associated with a receptor density map derived from positron emission tomography data.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125022001921_sec_a5\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Stable and decreasing were the most common trajectories. Additionally, cortical thickness abnormalities found at relatively late stages of FEP onset could be exploited as a biomarker of poor symptom outcome in the expressivity dimension. Finally, the brain areas with less density of receptors spatially overlap areas that discriminate the trajectories of the expressivity dimension.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.2022.192","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T10:19:00Z","timestamp":1676974740000},"page":"309-318","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":21,"title":["Longitudinal trajectories in negative symptoms and changes in brain cortical thickness: 10-year follow-up 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Author(s), 2023. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}