{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:48:03Z","timestamp":1791859683831,"version":"4.3.4"},"reference-count":10,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"funder":[{"name":"NIHR Oxford Health Biomedical Research Centre","award":["BRC-1215-20005"],"award-info":[{"award-number":["BRC-1215-20005"]}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    An antiviral effect of lithium has been proposed, but never investigated for coronavirus disease 2019 (COVID-19). Using electronic health records of 26 554 patients with documented serum lithium levels during the pandemic, we show that the 6-month COVID-19 infection incidence was lower among matched patients with \u2018therapeutic\u2019 (0.50\u20131.00) versus \u2018subtherapeutic\u2019 (0.05\u20130.50) lithium levels (hazard ratio (HR) = 0.82, 95% CI 0.69\u20130.97,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.017) and among patients with \u2018therapeutic\u2019 lithium levels versus matched patients using valproate (HR = 0.79, 95% CI 0.67\u20130.92,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0023). Lower rates of infection were observed for both new COVID-19 diagnoses and positive polymerase chain reaction tests, regardless of underlying psychiatric diagnosis and vaccination status.\n                  <\/jats:p>","DOI":"10.1192\/bjp.2022.42","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T07:15:25Z","timestamp":1648019725000},"page":"425-427","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":25,"title":["Association between serum lithium level and incidence of COVID-19 infection"],"prefix":"10.1192","volume":"221","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6883-0559","authenticated-orcid":false,"given":"Livia J.","family":"De Picker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Leboyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Geddes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Morrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6719-1126","authenticated-orcid":false,"given":"Paul J.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-952X","authenticated-orcid":false,"given":"Maxime","family":"Taquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"S0007125022000423_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2021.2503"},{"key":"S0007125022000423_ref2","doi-asserted-by":"publisher","DOI":"10.1080\/03079450601156083"},{"key":"S0007125022000423_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30462-4"},{"key":"S0007125022000423_ref7","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"},{"key":"S0007125022000423_ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-020-00191-4"},{"key":"S0007125022000423_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(21)00232-7"},{"key":"S0007125022000423_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(21)00448-4"},{"key":"S0007125022000423_ref10","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2021.1053"},{"key":"S0007125022000423_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(21)00084-5"},{"key":"S0007125022000423_ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-020-00208-y"}],"container-title":["The British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125022000423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T20:10:35Z","timestamp":1655669435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125022000423\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0007125022000423"],"URL":"https:\/\/doi.org\/10.1192\/bjp.2022.42","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,23]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2022. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}