{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:40:21Z","timestamp":1790397621412,"version":"4.1.0"},"reference-count":41,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["31O.041"],"award-info":[{"award-number":["31O.041"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec id=\"S0007125023001435_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Late-life depression has been associated with volume changes of the hippocampus. However, little is known about its association with specific hippocampal subfields over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125023001435_sec_a2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We investigated whether hippocampal subfield volumes were associated with prevalence, course and incidence of depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125023001435_sec_a3\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      We extracted 12 hippocampal subfield volumes per hemisphere with FreeSurfer v6.0 using\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      -weighted and fluid-attenuated inversion recovery 3T magnetic resonance images. Depressive symptoms were assessed at baseline and annually over 7 years of follow-up (9-item Patient Health Questionnaire). We used negative binominal, logistic, and Cox regression analyses, corrected for multiple comparisons, and adjusted for demographic, cardiovascular and lifestyle factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125023001435_sec_a4\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of\n                      <jats:italic>n<\/jats:italic>\n                      = 4174 participants were included (mean age 60.0 years, s.d. = 8.6, 51.8% female). Larger right hippocampal fissure volume was associated with prevalent depressive symptoms (odds ratio (OR) = 1.26, 95% CI 1.08\u20131.48). Larger bilateral hippocampal fissure (OR = 1.37\u20131.40, 95% CI 1.14\u20131.71), larger right molecular layer (OR = 1.51, 95% CI 1.14\u20132.00) and smaller right cornu ammonis (CA)3 volumes (OR = 0.61, 95% CI 0.48\u20130.79) were associated with prevalent depressive symptoms with a chronic course. No associations of hippocampal subfield volumes with incident depressive symptoms were found. Yet, lower left hippocampal amygdala transition area (HATA) volume was associated with incident depressive symptoms with chronic course (hazard ratio = 0.70, 95% CI 0.55\u20130.89).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125023001435_sec_a5\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Differences in hippocampal fissure, molecular layer and CA volumes might co-occur or follow the onset of depressive symptoms, in particular with a chronic course. Smaller HATA was associated with an increased risk of incident (chronic) depression. Our results could capture a biological foundation for the development of chronic depressive symptoms, and stresses the need to discriminate subtypes of depression to unravel its biological underpinnings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2023.143","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T23:55:30Z","timestamp":1700697330000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":20,"title":["Association of hippocampal subfield volumes with prevalence, course and incidence of depressive symptoms: The Maastricht Study"],"prefix":"10.1192","volume":"224","author":[{"given":"Jennifer","family":"Monereo-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobus F. 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Published by Cambridge University Press on behalf of the Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}