{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:02:33Z","timestamp":1791583353646,"version":"4.3.4"},"reference-count":38,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["217065\/Z\/19\/Z"],"award-info":[{"award-number":["217065\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MRC"],"award-info":[{"award-number":["MRC"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec id=\"S0007125023000235_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is still known about the long-term impact of childhood and adolescent persistent depression and anxiety in adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125023000235_sec_a2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the impact of persistent anxiety, depression, and comorbid anxiety and depression across childhood and adolescence on the development of multiple adverse outcomes in young adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125023000235_sec_a3\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This study used data from 8122 participants in the Avon Longitudinal Study of Parents and Children cohort. The Development and Well-Being Assessment (DAWBA) examined child anxiety and depression symptomatology. The DAWBA generalised anxiety and mood subscales at 8, 10 and 13 years were selected, and a measure of comorbid anxiety and depression symptoms was created at each time point. Further, several mental and physical health, substance misuse and education\/employment problems were assessed at 24 years. Latent class growth analyses were used to detect trajectories of anxiety, depression and comorbid anxiety and depression; and logistic regression to examine how persistent anxiety, depression or both were associated with adverse outcomes at 24 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125023000235_sec_a4\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All three classes with persistent anxiety, depression or both were significantly associated with presenting with any mental health problems and any education\/employment problem. Persistent high levels of depression and high levels of comorbid anxiety and depression, but not persistent high anxiety, were significantly associated with any physical health problem. High levels of comorbid anxiety and depression was the only DAWBA domain significantly associated with substance misuse; and overall, this was the domain that exerted the greatest negative impact, as it presented the highest odd ratio values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125023000235_sec_a5\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children and adolescents with comorbid anxiety and depression are at the highest risk for having more adverse outcomes at 24 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2023.23","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T03:20:39Z","timestamp":1678850439000},"page":"212-220","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":86,"title":["Impact of anxiety and depression across childhood and adolescence on adverse 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Published by Cambridge University Press on behalf of the Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}