{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:43:43Z","timestamp":1785282223077,"version":"3.55.0"},"reference-count":0,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"unspecified","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec id=\"S0007125024001193_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Anorexia nervosa is a psychiatric disorder characterised by undernutrition, significantly low body weight and large, although possibly transient, reductions in brain structure. Advanced brain ageing tracks accelerated age-related changes in brain morphology that have been linked to psychopathology and adverse clinical outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024001193_sec_a2\"><jats:title>Aim<\/jats:title><jats:p>The aim of the current case\u2013control study was to characterise cross-sectional and longitudinal patterns of advanced brain age in acute anorexia nervosa and during the recovery process.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024001193_sec_a3\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Measures of grey- and white-matter-based brain age were obtained from T1-weighted magnetic resonance imaging scans of 129 acutely underweight female anorexia nervosa patients (of which 95 were assessed both at baseline and after approximately 3 months of nutritional therapy), 39 recovered patients and 167 healthy female controls, aged 12\u201323 years. The difference between chronological age and grey- or white-matter-based brain age was calculated to indicate brain-predicted age difference (BrainAGE<jats:sub>GM<\/jats:sub> and BrainAGE<jats:sub>WM<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024001193_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Acute anorexia nervosa patients at baseline, but not recovered patients, showed a higher BrainAGE<jats:sub>GM<\/jats:sub> of 1.79 years (95% CI [1.45, 2.13]) compared to healthy controls. However, the difference was largely reduced for BrainAGE<jats:sub>WM<\/jats:sub>. After partial weight restoration, BrainAGE<jats:sub>GM<\/jats:sub> decreased substantially (beta = \u22121.69; CI [\u22121.93, \u22121.46]). BrainAGEs were unrelated to symptom severity or depression, but larger weight gain predicted larger normalisation of BrainAGE<jats:sub>GM<\/jats:sub> in the longitudinal patient sample (beta = \u22120.65; CI [\u22120.75, \u22120.54]).<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024001193_sec_a5\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that in patients with anorexia nervosa, undernutrition is an important predictor of advanced grey-matter-based brain age, which itself might be transient in nature and largely undetectable after weight recovery.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.2024.119","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T19:16:29Z","timestamp":1733944589000},"page":"499-505","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Transient patterns of advanced brain ageing in female adolescents with anorexia nervosa"],"prefix":"10.1192","volume":"225","author":[{"given":"Tatiana","family":"Stratton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5413-0359","authenticated-orcid":false,"given":"Klaas","family":"Bahnsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Geisler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bernardoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-4445","authenticated-orcid":false,"given":"Stefan","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-2200","authenticated-orcid":false,"given":"Esther","family":"Walton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2024,12,11]]},"container-title":["The British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125024001193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T19:17:12Z","timestamp":1733944632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125024001193\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0007125024001193"],"URL":"https:\/\/doi.org\/10.1192\/bjp.2024.119","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2024. Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}