{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:03:08Z","timestamp":1791644588095,"version":"4.3.4"},"reference-count":40,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C1C1003502"],"award-info":[{"award-number":["2020R1C1C1003502"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec id=\"S0007125024001703_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Breast cancer is a major global health issue, especially among women. Previous research has indicated a possible association between psychiatric conditions, particularly schizophrenia, and an increased risk of breast cancer. However, the specific risk of breast cancer in women with schizophrenia, compared with those with other psychiatric disorders and the general population, remains controversial and needs further clarification.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024001703_sec_a2\"><jats:title>Aims<\/jats:title><jats:p>To estimate the risk of breast cancer among people with schizophrenia compared with people with other psychiatric disorders and people in the general population.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024001703_sec_a3\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>We utilised medical claims data of women aged 18 to 80 years in the Korean National Health Information Database from 2007 to 2018. Individuals with schizophrenia were defined as women with ICD-10 codes F20 or F25 (<jats:italic>n<\/jats:italic> = 224 612). The control groups were defined as women with other psychiatric disorders (<jats:italic>n<\/jats:italic> = 224 612) and women in the general Korean population (<jats:italic>n<\/jats:italic> = 449 224). Cases and controls were matched by index date and age, in a 1:1:2 ratio. We estimated the hazard of breast cancer using the Cox proportional hazards model, adjusting for insurance premiums and medical comorbidities. Among the people with schizophrenia, we used the landmark method to estimate the association between duration of antipsychotic medication use and the incidence of breast cancer.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024001703_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>In multivariable Cox regression models, the hazard rate of breast cancer was 1.26 times higher in the people with schizophrenia than in the general population (95% CI: 1.20\u20131.32). In comparison with the psychiatric patient group, the hazard ratio was 1.17 (95% CI: 1.11\u20131.28). Among women with schizophrenia, the hazard of breast cancer was greater among those who took antipsychotic medications for 1 year or more compared with those who took antipsychotics for less than 6 months.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024001703_sec_a5\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Women with schizophrenia have an elevated risk of breast cancer, and long-term use of antipsychotics is associated with an increased risk of breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.2024.170","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T15:08:46Z","timestamp":1730387326000},"page":"206-212","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Breast cancer risk among women with schizophrenia and association with duration of antipsychotic use: population-based cohort study in South Korea"],"prefix":"10.1192","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5070-6923","authenticated-orcid":false,"given":"Ji Su","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunghyuk","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwanghyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6397-7917","authenticated-orcid":false,"given":"Alexander 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Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial licence (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}