{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:23:20Z","timestamp":1791872600654,"version":"4.3.4"},"reference-count":49,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 32271087"],"award-info":[{"award-number":["No. 32271087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec id=\"S0007125024002125_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Knowledge is growing on the essential role of neural circuits involved in aberrant cognitive control and reward sensitivity for the onset and maintenance of binge eating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024002125_sec_a2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate how the brain's reward (bottom-up) and inhibition control (top-down) systems potentially and dynamically interact to contribute to subclinical binge eating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024002125_sec_a3\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Functional magnetic resonance imaging data were acquired from 30 binge eaters and 29 controls while participants performed a food reward Go\/NoGo task. Dynamic causal modelling with the parametric empirical Bayes framework, a novel brain connectivity technique, was used to examine between-group differences in the directional influence between reward and executive control regions. We explored the proximal risk factors for binge eating and its neural basis, and assessed the predictive ability of neural indices on future disordered eating and body weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024002125_sec_a4\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The binge eating group relative to controls displayed fewer reward-inhibition undirectional and directional synchronisations (i.e. medial orbitofrontal cortex [mOFC]\u2013superior parietal gyrus [SPG] connectivity, mOFC \u2192 SPG excitatory connectivity) during food reward_nogo condition. Trait impulsivity is a key proximal factor that could weaken the mOFC\u2013SPG connectivity and exacerbate binge eating. Crucially, this core mOFC\u2013SPG connectivity successfully predicted binge eating frequency 6 months later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024002125_sec_a5\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings point to a particularly important role of the bottom-up interactions between cortical reward and frontoparietal control circuits in subclinical binge eating, which offers novel insights into the neural hierarchical mechanisms underlying problematic eating, and may have implications for the early identification of individuals suffering from strong binge eating-associated symptomatology in the general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2024.212","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T03:38:03Z","timestamp":1737430683000},"page":"442-455","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Functional and effective connectivity between reward and inhibitory control networks underlying subclinical binge eating"],"prefix":"10.1192","volume":"227","author":[{"given":"Ximei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-7028","authenticated-orcid":false,"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"S0007125024002125_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-013-0694-y"},{"key":"S0007125024002125_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2017.08.006"},{"key":"S0007125024002125_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2018.12.002"},{"key":"S0007125024002125_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291722003026"},{"key":"S0007125024002125_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.02.020"},{"key":"S0007125024002125_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.06.032"},{"key":"S0007125024002125_ref45","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-023-01617-5"},{"key":"S0007125024002125_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsv053"},{"key":"S0007125024002125_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000895"},{"key":"S0007125024002125_ref39","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1995.10476572"},{"key":"S0007125024002125_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2018.12.043"},{"key":"S0007125024002125_ref1","unstructured":"1 Deloitte Access Economics. 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