{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:35:13Z","timestamp":1782228913942,"version":"3.54.5"},"reference-count":39,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO.72204071"],"award-info":[{"award-number":["NO.72204071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec id=\"S0007125024002277_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Evidence is largely limited regarding the extent to which abnormal behavioural profiles, including physical inactivity, sedentary behaviour and inadequate sleep duration, impact long-term health conditions in individuals with pre-existing depression.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024002277_sec_a2\"><jats:title>Aims<\/jats:title><jats:p>To investigate the associations between accelerometer-derived daily movement behaviours and mortality in individuals with pre-existing depression.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024002277_sec_a3\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Between 2013 and 2015, a total of 10 914 individuals with pre-existing depression were identified from the UK Biobank through multiple sources including self-reported symptoms, records of antidepressant usage and diagnostic recording based on the 10th Revision of the International Classification of Diseases (ICD-10) codes F32\u2013F33. These participants were subsequently followed up until 2021. Wrist-worn accelerometers were used for objective measurement of sleep duration, sedentary behaviour, moderate-to-vigorous physical activity (MVPA) and light physical activity (LPA) over a span of seven consecutive days.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024002277_sec_a4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>During a median follow-up of 6.9 years, 434 deaths occurred among individuals with pre-existing depression. We observed a U-shaped association between sleep duration and mortality in individuals with pre-existing depression, with the lowest risk occurring at approximately 9 h\/day. Both MVPA and LPA exhibited an L-shaped pattern in relation to mortality, indicating that engaging in higher levels of physical activity was associated with lower risk of mortality in individuals with pre-existing depression, but the beneficial effect reached a plateau after 50 min\/day for MVPA and 350 min\/day for LPA. We found a positive association between sedentary time and mortality, and the risk apparently increased above 8 h\/day. Moreover, substituting 1 hour\/day of sedentary time with LPA or MVPA was significantly associated with a 12% (hazard ratio: 0.88, 95% CI: 0.83\u20130.94) and 24% (hazard ratio: 0.76, 95% CI: 0.61\u20130.94) lower risk of mortality, respectively.<\/jats:p><\/jats:sec><jats:sec id=\"S0007125024002277_sec_a5\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Our study found the beneficial effect of adequate sleep duration, high levels of physical activity and short sedentary time on risk of mortality among individuals with pre-existing depression.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.2024.227","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T05:18:00Z","timestamp":1733289480000},"page":"525-532","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Accelerometer-derived movement behaviours and risk of mortality among individuals with pre-existing depression: prospective cohort study"],"prefix":"10.1192","volume":"227","author":[{"given":"Tingshan","family":"Duan","sequence":"first","affiliation":[{"name":"Hangzhou Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-734X","authenticated-orcid":false,"given":"Zhi","family":"Cao","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Wang","sequence":"additional","affiliation":[{"name":"Hangzhou Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Min","sequence":"additional","affiliation":[{"name":"Hangzhou Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Hangzhou Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Luo","sequence":"additional","affiliation":[{"name":"Hangzhou Seventh People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8997-9299","authenticated-orcid":false,"given":"Chenjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Hangzhou Normal University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"S0007125024002277_ref16","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12654"},{"key":"S0007125024002277_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glad108"},{"key":"S0007125024002277_ref26","volume-title":"Health and Deprivation: Inequality and the North","author":"Townsend","year":"1988"},{"key":"S0007125024002277_ref34","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab580"},{"key":"S0007125024002277_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05563-7"},{"key":"S0007125024002277_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.10.131"},{"key":"S0007125024002277_ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2022-106195"},{"key":"S0007125024002277_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.10.020"},{"key":"S0007125024002277_ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-7919-2"},{"key":"S0007125024002277_ref32","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4570"},{"key":"S0007125024002277_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-1173-2"},{"key":"S0007125024002277_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"S0007125024002277_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2021-105195"},{"key":"S0007125024002277_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2022.09.016"},{"key":"S0007125024002277_ref33","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955"},{"key":"S0007125024002277_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0380-1"},{"key":"S0007125024002277_ref28","doi-asserted-by":"publisher","DOI":"10.1177\/0962280217737805"},{"key":"S0007125024002277_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0633-x"},{"key":"S0007125024002277_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12236"},{"key":"S0007125024002277_ref2","unstructured":"2 World Health Organization. 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