{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:01:47Z","timestamp":1785315707482,"version":"3.55.0"},"reference-count":39,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec id=\"S0007125024002824_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The identification of early warning signs is of great importance for identifying individuals at risk for mental disorders. Especially in the case of bipolar disorder, these research endeavours are imperative considering that the frequently delayed diagnoses and longer illness duration are associated with symptom exacerbation and lower recovery rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024002824_as2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To multimodally investigate associations between hypomanic personality traits and altered social affect and social cognition to probe their role as early warning signs of bipolar disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024002824_as3\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In a community sample (\n                      <jats:italic>n<\/jats:italic>\n                      = 140; 50.71% female), we investigated associations between hypomanic personality traits and both behavioural and neural activity measures of empathy and theory of mind (ToM) based on data from a functional magnetic resonance imaging paradigm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024002824_as4\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although analyses revealed no significant associations between behavioural or neural correlates of empathy and hypomanic personality traits, these traits were significantly associated with elevated ToM-related neural activity in the anterior rostral medial prefrontal cortex and anterior cingulate cortex. These neural activation differences were not accompanied by differences in behavioural ToM performance, suggesting more intense recruitment of task-relevant brain regions but unaffected behavioural outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024002824_as5\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate hypomanic personality traits to be positively associated with ToM-related neural activity but not with behavioural ToM performance. Prospectively, our study contributes to driving towards a more comprehensive and potentially neurobiologically grounded phenotype of bipolar disorder risk that contributes to\u00a0a more differential understanding of risk and resilience mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2024.282","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T03:49:54Z","timestamp":1745984994000},"page":"126-132","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Neural correlates of social affect and social cognition as risk markers of bipolar disorder"],"prefix":"10.1192","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6372-4747","authenticated-orcid":false,"given":"Dahna","family":"Choi","sequence":"first","affiliation":[{"name":"TUD Dresden University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3041-9246","authenticated-orcid":false,"given":"Katharina","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"TUD Dresden University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6450-0600","authenticated-orcid":false,"given":"Malin Katharina","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"TUD Dresden University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-7471","authenticated-orcid":false,"given":"Lara Zo\u00eb","family":"Maliske","sequence":"additional","affiliation":[{"name":"TUD Dresden University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Lehmann","sequence":"additional","affiliation":[{"name":"TUD Dresden University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-8782","authenticated-orcid":false,"given":"Philipp","family":"Kanske","sequence":"additional","affiliation":[{"name":"TUD Dresden University of Technology"},{"name":"Babe\u015f-Bolyai University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3267-1688","authenticated-orcid":false,"given":"Emanuel","family":"Jauk","sequence":"additional","affiliation":[{"name":"Medical University of Graz"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"S0007125024002824_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s10862-023-10098-w"},{"key":"S0007125024002824_ref14","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2009.21.1.59"},{"key":"S0007125024002824_ref27","doi-asserted-by":"publisher","DOI":"10.1037\/a0022301"},{"key":"S0007125024002824_ref36","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128197"},{"key":"S0007125024002824_ref17","doi-asserted-by":"publisher","DOI":"10.1177\/0004867420924109"},{"key":"S0007125024002824_ref7","doi-asserted-by":"publisher","DOI":"10.4324\/9781003051817-18"},{"key":"S0007125024002824_ref39","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12081044"},{"key":"S0007125024002824_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1986.tb10594.x"},{"key":"S0007125024002824_ref33","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab125"},{"key":"S0007125024002824_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.01.015"},{"key":"S0007125024002824_ref20","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.95.3.214"},{"key":"S0007125024002824_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117624"},{"key":"S0007125024002824_ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-021-00221-9"},{"key":"S0007125024002824_ref6","doi-asserted-by":"publisher","DOI":"10.1026\/1616-3443\/a000648"},{"key":"S0007125024002824_ref28","unstructured":"28 Paulus, DC. 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Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}