{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:50:44Z","timestamp":1785513044510,"version":"3.56.0"},"reference-count":40,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec id=\"S0007125024003040_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Having a relapse of schizophrenia or recurrent psychosis is feared by patients, can cause social and personal disruption and has been suggested to cause long-term deterioration, possibly because of a toxic biological process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024003040_as2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess whether relapse affected the social and clinical outcomes of people enrolled in a 24-month randomised controlled trial of antipsychotic medication dose reduction versus maintenance treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024003040_as3\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The trial involved participants with a diagnosis of schizophrenia or recurrent, non-affective psychosis. Relapse was defined as admission to hospital or significant deterioration (assessed by a blinded end-point committee). We analysed the relationship between relapse during the trial and social functioning, quality of life, symptom scores (Positive and Negative Syndrome Scale) and rates of being in employment, education or training at 24-month follow-up. We also analysed changes in these measures during the trial among those who relapsed and those who did not. Sensitivity analyses were conducted examining the effects of \u2018severe\u2019 relapse (i.e. admission to hospital).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024003040_as4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the course of the trial, 82 out of 253 participants relapsed. There was no evidence for a difference between those who relapsed and those who did not on changes in social functioning, quality of life, symptom scores or overall employment rates between baseline and 24-month follow-up. Those who relapsed showed no change in their social functioning or quality of life, and a slight improvement in symptoms compared to baseline. They were more likely than those who did not relapse to have had a change in their employment status (mostly moving out of employment, education or training), although numbers changing status were small. Sensitivity analyses showed the same results for those who experienced a \u2018severe\u2019 relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024003040_as5\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data provide little evidence that relapse has a detrimental effect in the long term in people with schizophrenia and recurrent psychosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2024.304","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T08:45:50Z","timestamp":1744620350000},"page":"673-679","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["The association between relapse and the outcome of schizophrenia and recurrent psychotic disorders"],"prefix":"10.1192","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1214-6974","authenticated-orcid":false,"given":"Joanna","family":"Moncrieff","sequence":"first","affiliation":[{"name":"University College London"},{"name":"North East London Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Pillai","sequence":"additional","affiliation":[{"name":"North East London Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9973-1131","authenticated-orcid":false,"given":"Louise","family":"Marston","sequence":"additional","affiliation":[{"name":"Research Department of Primary Care and Population Health, University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-8245","authenticated-orcid":false,"given":"Glyn","family":"Lewis","sequence":"additional","affiliation":[{"name":"University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2324-656X","authenticated-orcid":false,"given":"Thomas R. 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Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}