{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:54:07Z","timestamp":1791924847213,"version":"4.3.4"},"reference-count":36,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec id=\"S0007125024000990_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anxiety disorders are a major public health burden with limited treatment options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024000990_sec_a2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We investigated the long-term safety and efficacy of lysergic acid diethylamide (LSD)-assisted therapy in patients with anxiety with or without life-threatening illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024000990_sec_a3\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      This study was an\n                      <jats:italic>a priori<\/jats:italic>\n                      -planned long-term follow-up of an investigator-initiated, two-centre trial that used a double-blind, placebo-controlled, two-period, random-order, crossover design with two sessions with either oral LSD (200 \u03bcg) or placebo per period. Participants (\n                      <jats:italic>n<\/jats:italic>\n                      = 39) were followed up 1 year after the end-of-study visit to assess symptoms of anxiety, depression and long-term effects of psychedelics using Spielberger's State-Trait Anxiety Inventory\u2013Global (STAI-G), the Beck Depression Inventory (BDI), the Persisting Effects Questionnaire and measures of personality traits using the NEO\n                      <jats:bold>-<\/jats:bold>\n                      Five-Factor Inventory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024000990_sec_a4\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants reported a sustained reduction of STAI-G scores compared with baseline (least square means (95% CI) = \u221221.6 (\u221232.7, \u221210.4),\n                      <jats:italic>d<\/jats:italic>\n                      = 1.04,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001, for those who received LSD in the first period (94 weeks after the last LSD treatment) and \u221216.5 (\u221226.2, \u22126.8),\n                      <jats:italic>d<\/jats:italic>\n                      = 1.02,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05, for those who received LSD in the second period (68 weeks after the last LSD treatment)). Similar effects were observed for comorbid depression with change from baseline BDI scores of \u22128.1 (\u221213.2, \u22123.1),\n                      <jats:italic>d<\/jats:italic>\n                      = 0.71,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01, and \u22128.9 (\u221212.9, \u22124.9),\n                      <jats:italic>d<\/jats:italic>\n                      = 1.21,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01, for the LSD-first and placebo-first groups, respectively. Personality trait neuroticism decreased (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) and trait extraversion increased (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.01) compared with study inclusion. Individuals attributed positive long-term effects to the psychedelic experience.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125024000990_sec_a5\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients reported sustained long-term effects of LSD-assisted therapy for anxiety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2024.99","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T07:43:38Z","timestamp":1722325418000},"page":"362-370","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":38,"title":["LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up"],"prefix":"10.1192","volume":"225","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3143-1519","authenticated-orcid":false,"given":"Friederike","family":"Holze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Strebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-9659","authenticated-orcid":false,"given":"Matthias E.","family":"Liechti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"S0007125024000990_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675512"},{"key":"S0007125024000990_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2017_474"},{"key":"S0007125024000990_ref34","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00974"},{"key":"S0007125024000990_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111420188"},{"key":"S0007125024000990_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291723001514"},{"key":"S0007125024000990_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.3285"},{"key":"S0007125024000990_ref28","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6401_2"},{"key":"S0007125024000990_ref32","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712001882"},{"key":"S0007125024000990_ref1","first-page":"4","article-title":"The 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Author(s), 2024. Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}