{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:13:55Z","timestamp":1788498835175,"version":"build-2803163510"},"reference-count":27,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec id=\"S0007125025103413_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Depressive symptoms are common in mild cognitive impairment (MCI). These may be associated with poorer cognitive function and increased risks of dementia transition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025103413_as2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to examine the cognitive patterns associated with variations in depressive symptoms in neurodegenerative MCI without a primary mood disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025103413_as3\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Individuals with MCI (\n                      <jats:italic>n<\/jats:italic>\n                      = 123), including MCI due to Alzheimer\u2019s disease (\n                      <jats:italic>n<\/jats:italic>\n                      = 54) and MCI with Lewy bodies (\n                      <jats:italic>n<\/jats:italic>\n                      = 69), underwent repeated annual assessment of cognitive function and concurrent depressive symptoms using the Addenbrooke\u2019s Cognitive Examination-Revised and the Geriatric Depression Scale-15, respectively.\n                    <\/jats:p>\n                    <jats:p>Between- and within-person differences in depressive symptoms were disaggregated and related to between- and within-person cognitive differences and modification of cognitive performance trajectories over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025103413_as4\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was strong evidence of a state-based association between depressive symptoms and cognitive function. Intra-individual differences in depressive symptoms were negatively associated with concurrent cognitive performance such that a 2-point increase in depressive score explained a 1-point decrease in cognitive score, on average (point estimate \u22120.56, 95% credibile interval (CrI) \u22121.05 to \u22120.08).<\/jats:p>\n                    <jats:p>The data did not support a trait-based association between depressive symptoms and cognitive performance (point estimate 0.10, 95% CrI \u22120.42 to 0.59), nor any between- or within-person trajectory modification associated with depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025103413_as5\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within-person variations in depressive symptom severity are associated with acute cognitive performance differences. Cognitive scores derived during active depressive periods may underestimate longer-term cognitive capabilities. Treating depressive symptoms in MCI may clarify underlying cognitive performance capacity, and help maintain optimal cognitive function for longer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2025.10341","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:46:28Z","timestamp":1756284388000},"page":"286-291","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Cross-sectional and longitudinal associations between depressive symptoms and cognitive performance in mild cognitive impairment"],"prefix":"10.1192","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-3150","authenticated-orcid":false,"given":"Calum A.","family":"Hamilton","sequence":"first","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Donaghy","sequence":"additional","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Paul","family":"Taylor","sequence":"additional","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Ciafone","sequence":"additional","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Durcan","sequence":"additional","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Firbank","sequence":"additional","affiliation":[{"name":"Newcastle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Greenfinch","sequence":"additional","affiliation":[{"name":"Newcastle University"},{"name":"University College London Hospitals"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise M.","family":"Allan","sequence":"additional","affiliation":[{"name":"University of Exeter"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0837-5080","authenticated-orcid":false,"given":"John T.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"University of Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Newcastle 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2025. Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}