{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:45:01Z","timestamp":1786545901308,"version":"build-2736575974"},"reference-count":40,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec id=\"S0007125025000042_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Involuntary treatment for patients with anorexia nervosa is common and lifesaving, but also highly intrusive. Understanding how morbidity patterns relate to involuntary treatment can help minimise its use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025000042_as2\">\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We estimate the relative risk of involuntary treatment according to morbidity profiles in patients with anorexia nervosa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025000042_as3\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This register-based cohort study included all individuals diagnosed with anorexia nervosa (ICD-10: F50.0, F50.1) between 1 January 2000 and 31 December 2016 in Denmark. Individuals were grouped by prior morbidities using latent class analysis (LCA). Cox proportional hazards regression estimated the relative risk of first involuntary treatment (e.g. involuntary admission, detention, locked wards) after a diagnosis with anorexia nervosa, regardless of the associated\u00a0diagnosis. The relative risk of involuntary treatment was estimated with latent classes and the number of morbidities as exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025000042_as4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 9892 individuals with anorexia nervosa were included (93.3% female), of which 821 (8.3%) individuals experienced at least one involuntary treatment event. The LCA produced six classes, with distinct morbidity profiles. The highest hazard ratio was observed for a group characterised by personality disorders, self-harm and substance misuse (hazard ratio 4.46, 95% CI: 3.43\u20135.79) followed by a high burden group with somatic and psychiatric disorders (hazard ratio 3.96, 95% CI: 2.81\u20135.59) and a group with developmental and behavioural disorders (hazard ratio 3.61, 95% CI: 2.54\u20135.11). The relative risk of involuntary treatment increased primarily with the number of psychiatric morbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025000042_as5\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Specific morbidity groups are associated with highly elevated risk of involuntary treatment among patients with anorexia nervosa. Targeting preventive interventions to high-risk groups may help reduce the need for involuntary treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2025.4","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T05:03:55Z","timestamp":1743743035000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Psychiatric and somatic morbidity patterns among patients diagnosed with anorexia nervosa and the risk of involuntary treatment: register-based cohort study"],"prefix":"10.1192","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-2808","authenticated-orcid":false,"given":"Line","family":"Bager","sequence":"first","affiliation":[{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Chatwin","sequence":"additional","affiliation":[{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Holde","sequence":"additional","affiliation":[{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-7066","authenticated-orcid":false,"given":"Birgitte Dige","family":"Semark","sequence":"additional","affiliation":[{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdulkadir","sequence":"additional","affiliation":[{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Mac Donald","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-8347","authenticated-orcid":false,"given":"Loa","family":"Clausen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital Psychiatry"},{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liselotte Vogdrup","family":"Petersen","sequence":"additional","affiliation":[{"name":"Aarhus University"},{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"S0007125025000042_ref18","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2021.104"},{"key":"S0007125025000042_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22624"},{"key":"S0007125025000042_ref24","unstructured":"24 Sundhedsstyrelsen. 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Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}