{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T07:51:15Z","timestamp":1785657075727,"version":"3.56.0"},"reference-count":39,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec id=\"S0007125025000674_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Assessment of regional glucose metabolism by [\n                      <jats:sup>18<\/jats:sup>\n                      F]fluorodeoxyglucose position emission tomography ([\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET) serves as a biomarker for differential diagnosis of dementia. Conversely, depressive cognitive impairment shows no abnormalities on cerebral [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025000674_as2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      This study validates the diagnostic value of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET in addition to clinical diagnosis in a real-life gerontopsychiatric clinical population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025000674_as3\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Ninety-eight consecutive patients with depression and cognitive impairment were included. Baseline clinical diagnoses were independently established before and after disclosure of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET, and dichotomised into neurodegenerative or non-neurodegenerative diseases (level 1). Subsequently, neurodegenerative cases were allocated to diagnostic subgroups (Alzheimer\u2019s disease, Lewy body diseases, frontotemporal lobar degeneration, neurodegenerative other; level 2). An interdisciplinary, biomarker-supported consensus diagnosis after a median follow-up of 6.6 month after [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET served as reference. Changes of clinical diagnoses and diagnostic accuracy were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025000674_as4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After disclosure of [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET, level-1 clinical diagnoses changed in 23% (95% CI 16\u201333%) of cases, improving the diagnostic accuracy from 72% (95% CI 62\u201381%) to 92% (95% CI 84\u201396%) (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET was of particular value for exclusion of neurodegenerative disease. Concerning level-2 decisions, the clinical diagnoses changed in 30% (95% CI 21\u201340%) of cases, increasing its accuracy from 64% (95% CI 54\u201374%) to 85% (95% CI 76\u201391%) (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). A major fraction of incorrect level-2 diagnoses comprised Alzheimer\u2019s disease misdiagnosed as Lewy body diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125025000674_as5\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET provides a significant incremental diagnostic value beyond the clinical diagnosis in depressive cognitive impairment. Thus, [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG PET should be considered in the diagnostic work-up of patients with mental disorders and cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2025.67","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T05:55:15Z","timestamp":1746683715000},"page":"332-339","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["[\n                    <sup>18<\/sup>\n                    F]Fluorodeoxyglucose position emission tomography for differential diagnosis of depressive cognitive impairment: incremental value compared with clinical diagnosis"],"prefix":"10.1192","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-2588","authenticated-orcid":false,"given":"Sabine","family":"Hellwig","sequence":"first","affiliation":[{"name":"University of 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