{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:54:28Z","timestamp":1791366868715,"version":"4.3.1"},"reference-count":65,"publisher":"Royal College of Psychiatrists","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Psychiatry"],"abstract":"<jats:sec id=\"S0007125026107764_as1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125026107764_as2\">\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes implicated in lithium response and\/or bipolar disorder aetiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125026107764_as3\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      We analysed data collected from bipolar disorder patients who had received lithium treatment for at least 6 months and participated in the International Consortium on Lithium Genetics study (\n                      <jats:italic>N<\/jats:italic>\n                      = 2367). The Alda scale was used to assess lithium responsiveness, and treatment outcome was defined as continuous total Alda score (0\u201310) and categorical outcome (favourable \u22657 versus unfavourable response). PGSs were calculated for 60 phenotypes grouped into 5 clinical\u2013biological clusters: psychiatric and behavioural (#23 phenotypes), cardiometabolic (#17), autoimmune\/inflammatory (#5), neurocognitive (#8) and renal function (#7). We applied cross-validated machine learning regression approaches in both outcomes within each cluster, with the selected features from each cluster subsequently combined to construct the final mt-PGS models. Model performance was assessed using explained variance (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ) for the continuous outcome, and both McFadden\u2019s pseudo-\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      and standard classification model parameters for the categorical outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125026107764_as4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>mt-PGS explained between 5.70% (continuous outcome) and 9.11% (categorical outcome) of the interindividual variability in lithium responsiveness. Classification accuracy (area under the curve) for the categorical outcome was 68.24% (95% CI: 64.98\u201371.66), with a Brier score of 0.257. Of the 5 clusters, the PGSs for psychiatric and behavioural phenotypes were most strongly associated with lithium responsiveness, accounting for 3.67\u20136.52% of its variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0007125026107764_as5\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>By integrating PGSs for multiple relevant phenotypes, predictive accuracy for lithium response improved substantially compared with single-trait methods. Future research incorporating larger, more diverse populations and combining genetic scores with clinical data holds promise for further enhancing prediction and advancing clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.2026.10776","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:28:35Z","timestamp":1791365315000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder"],"prefix":"10.1192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-6992","authenticated-orcid":false,"given":"Nigussie T.","family":"Sharew","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/028g18b61","id-type":"ROR","asserted-by":"publisher"}],"name":"Adelaide University"},{"name":"Debre Berhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-5611","authenticated-orcid":false,"given":"Scott R.","family":"Clark","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/028g18b61","id-type":"ROR","asserted-by":"publisher"}],"name":"Adelaide University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Hartmann","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/028g18b61","id-type":"ROR","asserted-by":"publisher"}],"name":"Adelaide University"},{"name":"Orygen"},{"name":"University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Papiol","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"},{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Heilbronner","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Degenhardt","sequence":"additional","affiliation":[{"name":"University Hospital, Faculty of Medicine, University of Bonn"},{"name":"University of Duisburg-Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice M.","family":"Fullerton","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia"},{"name":"University of New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Hou","sequence":"additional","affiliation":[{"name":"National Institutes of Health, United States Department of Health and Human Services"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Shekhtman","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazda","family":"Adli","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmala","family":"Akula","sequence":"additional","affiliation":[{"name":"National Institutes of Health, United States Department of Health and Human Services"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazufumi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Dokkyo Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Ardau","sequence":"additional","affiliation":[{"name":"Hospital University Agency of Cagliari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Arias","sequence":"additional","affiliation":[{"name":"University of Barcelona"},{"name":"Carlos III Health Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fasil","family":"Tekola-Ayele","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Gallo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias e Ingenier\u00eda, Universidad Peruana Cayetano Heredia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Hasler","sequence":"additional","affiliation":[{"name":"HUG - Geneva University Hospitals"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Richard-Lepouriel","sequence":"additional","affiliation":[{"name":"HUG - Geneva University Hospitals"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Perroud","sequence":"additional","affiliation":[{"name":"HUG - Geneva University Hospitals"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Backlund","sequence":"additional","affiliation":[{"name":"Karolinska Institute"},{"name":"Karolinska University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abesh K.","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bellivier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Psychiatrie et de M\u00e9decine Addictologique, L\u2019Assistance Publique-H\u00f4pitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisi\u00e8re-F.Widal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Benabarre","sequence":"additional","affiliation":[{"name":"University of Barcelona, IDIBAPS, CIBERSAM"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Bengesser","sequence":"additional","affiliation":[{"name":"Medical University of Graz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M.","family":"Biernacka","sequence":"additional","affiliation":[{"name":"Mayo Clinic"},{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Birner","sequence":"additional","affiliation":[{"name":"Medical University of Graz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Marie-Claire","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Psychiatrie et de M\u00e9decine Addictologique, L\u2019Assistance Publique-H\u00f4pitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisi\u00e8re-F.Widal"},{"name":"Optimisation Th\u00e9rapeutique en Neuropsychopharmacologie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Cervantes","sequence":"additional","affiliation":[{"name":"McGill University Health Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-0093","authenticated-orcid":false,"given":"Hsi-Chung","family":"Chen","sequence":"additional","affiliation":[{"name":"National Taiwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Chillotti","sequence":"additional","affiliation":[{"name":"Hospital University Agency of Cagliari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Cichon","sequence":"additional","affiliation":[{"name":"University Hospital Basel"},{"name":"University Hospital Basel"},{"name":"Research Centre J\u00fclich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Cruceana","sequence":"additional","affiliation":[{"name":"McGill University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr M.","family":"Czerski","sequence":"additional","affiliation":[{"name":"Poznan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Dalkner","sequence":"additional","affiliation":[{"name":"Medical University of Graz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Del","family":"Zompo","sequence":"additional","affiliation":[{"name":"University of Cagliari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Raymond","family":"DePaulo","sequence":"additional","affiliation":[{"name":"Johns Hopkins University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-1488","authenticated-orcid":false,"given":"Bruno","family":"\u00c9tain","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Psychiatrie et de M\u00e9decine Addictologique, L\u2019Assistance Publique-H\u00f4pitaux de Paris, Groupe Hospitalier Saint-Louis-Lariboisi\u00e8re-F.Widal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-4100","authenticated-orcid":false,"given":"St\u00e9phane","family":"Jamain","sequence":"additional","affiliation":[{"name":"Translational Neuropsychiatry, Fondation FondaMental"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Falkai","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry"},{"name":"Partner site Munich-Augsburg"},{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas J.","family":"Forstner","sequence":"additional","affiliation":[{"name":"Research Centre J\u00fclich"},{"name":"University Hospital, Faculty of Medicine, University of Bonn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Frisen","sequence":"additional","affiliation":[{"name":"Karolinska Institute"},{"name":"Karolinska Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Frye","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Gard","sequence":"additional","affiliation":[{"name":"H\u00f4pital Charles Perrens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie S.","family":"Garnham","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando S.","family":"Goes","sequence":"additional","affiliation":[{"name":"Johns Hopkins University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Grigoroiu-Serbanescu","sequence":"additional","affiliation":[{"name":"Alexandru Obregia Clinical Psychiatric Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas J.","family":"Fallgatter","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen"},{"name":"partner site T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Stegmaier","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ethofer","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen"},{"name":"University of T\u00fcbingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Biere","sequence":"additional","affiliation":[{"name":"University Hospital of Frankfurt, Goethe University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiyana","family":"Petrova","sequence":"additional","affiliation":[{"name":"University Hospital of Frankfurt, Goethe University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceylan","family":"Schuster","sequence":"additional","affiliation":[{"name":"University Hospital of Frankfurt, Goethe University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7501-9556","authenticated-orcid":false,"given":"Kristina","family":"Adorjan","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"},{"name":"University of Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Budde","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Heilbronner","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-4214","authenticated-orcid":false,"given":"Janos L.","family":"Kalman","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"},{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-2636","authenticated-orcid":false,"given":"Mojtaba O.","family":"Kohshour","sequence":"additional","affiliation":[{"name":"Ahvaz Jundishapur University of Medical Sciences"},{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Reich-Erkelenz","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina K.","family":"Schaupp","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-5672","authenticated-orcid":false,"given":"Eva C.","family":"Schulte","sequence":"additional","affiliation":[{"name":"Partner site Munich-Augsburg"},{"name":"University Hospital, Ludwig Maximilian University of Munich"},{"name":"Ahvaz Jundishapur University of Medical Sciences"},{"name":"University of Bonn"},{"name":"University Hospital, Ludwig Maximilian University of Munich"},{"name":"University Hospital, Faculty of Medicine, University of Bonn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3375-5314","authenticated-orcid":false,"given":"Fanny","family":"Senner","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"},{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Vogl","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion-George","family":"Anghelescu","sequence":"additional","affiliation":[{"name":"Mental Health Institute Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Arolt","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Dannlowski","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef E.","family":"Dietrich","sequence":"additional","affiliation":[{"name":"AMEOS Clinical Center Hildesheim"},{"name":"Center for Systems Neuroscience"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Figge","sequence":"additional","affiliation":[{"name":"European Medical School Oldenburg-Groningen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Ulm University, Bezirkskrankenhaus G\u00fcnzburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian U.","family":"Lang","sequence":"additional","affiliation":[{"name":"Ulm University, Bezirkskrankenhaus G\u00fcnzburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-9620","authenticated-orcid":false,"given":"Georg","family":"Juckel","sequence":"additional","affiliation":[{"name":"Ruhr University Bochum, LWL University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Konrad","sequence":"additional","affiliation":[{"name":"Agaplesion Diaconic Hospital Rotenburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Reimer","sequence":"additional","affiliation":[{"name":"University Medical Centre Hamburg-Eppendorf"},{"name":"Health North Hospital Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Schmau\u00df","sequence":"additional","affiliation":[{"name":"Bezirkskrankenhaus Augsburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry"},{"name":"University Hospital, Ludwig Maximilian University of Munich"},{"name":"Institute of Psychiatry, University of Sao Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Spitzer","sequence":"additional","affiliation":[{"name":"University Medical Center Rostock"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Von Hagen","sequence":"additional","affiliation":[{"name":"Clinical Centre Werra-Meissner"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"University Medical Centre G\u00f6ttingen"},{"name":"University of G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Karl-Jaspers-Klinik"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2917-5889","authenticated-orcid":false,"given":"Till F. M.","family":"Andlauer","sequence":"additional","affiliation":[{"name":"Technical University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Fischer","sequence":"additional","affiliation":[{"name":"University of G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bermpohl","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Ritter","sequence":"additional","affiliation":[{"name":"TUD Dresden University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Matura","sequence":"additional","affiliation":[{"name":"University Hospital of Frankfurt, Goethe University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gryaznova","sequence":"additional","affiliation":[{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Falkenberg","sequence":"additional","affiliation":[{"name":"Philipps-University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00fcneyt","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Philipps-University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Kircher","sequence":"additional","affiliation":[{"name":"Philipps-University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Schmidt","sequence":"additional","affiliation":[{"name":"University Medical Center G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Koch","sequence":"additional","affiliation":[{"name":"University Medical Center G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-0579","authenticated-orcid":false,"given":"Kathrin","family":"Gade","sequence":"additional","affiliation":[{"name":"University Medical Centre G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Trost","sequence":"additional","affiliation":[{"name":"University Medical Centre G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida S.","family":"Haussleiter","sequence":"additional","affiliation":[{"name":"Ruhr University Bochum, LWL University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lambert","sequence":"additional","affiliation":[{"name":"University Medical Centre Hamburg-Eppendorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja C.","family":"Rohenkohl","sequence":"additional","affiliation":[{"name":"University Medical Centre Hamburg-Eppendorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Kraft","sequence":"additional","affiliation":[{"name":"University Medical Centre Hamburg-Eppendorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Grof","sequence":"additional","affiliation":[{"name":"Mood Disorders Center of Ottawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"National Center of Neurology and Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Hauser","sequence":"additional","affiliation":[{"name":"Poznan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Herms","sequence":"additional","affiliation":[{"name":"University Hospital Basel"},{"name":"University Hospital, Faculty of Medicine, University of Bonn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hoffman","sequence":"additional","affiliation":[{"name":"University Hospital Basel"},{"name":"University Hospital, Faculty of Medicine, University of Bonn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"University of Barcelona, IDIBAPS, CIBERSAM"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Kahn","sequence":"additional","affiliation":[{"name":"Centre Psychoth\u00e9rapique de Nancy, Universit\u00e9 de Lorraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla","family":"Kassem","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-3587","authenticated-orcid":false,"given":"Po-Hsiu","family":"Kuo","sequence":"additional","affiliation":[{"name":"National Taiwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadafumi","family":"Kato","sequence":"additional","affiliation":[{"name":"RIKEN Brain Science Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kelsoe","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kittel-Schneider","sequence":"additional","affiliation":[{"name":"University Hospital Frankfurt"},{"name":"University Hospital of W\u00fcrzburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Ferensztajn-Rochowiak","sequence":"additional","affiliation":[{"name":"Poznan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Landesklinikum Neunkirchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Kusumi","sequence":"additional","affiliation":[{"name":"Hokkaido University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Laje","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Land\u00e9n","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Academy at the Gothenburg University"},{"name":"Karolinska Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4987-2718","authenticated-orcid":false,"given":"Catharina","family":"Lavebratt","sequence":"additional","affiliation":[{"name":"Karolinska Institute"},{"name":"Karolinska University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Leboyer","sequence":"additional","affiliation":[{"name":"AP-HP, Fondation FondaMental"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan G.","family":"Leckband","sequence":"additional","affiliation":[{"name":"VA San Diego Healthcare System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Tortorella","sequence":"additional","affiliation":[{"name":"University of Perugia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Manchia","sequence":"additional","affiliation":[{"name":"University of Cagliari"},{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Martinsson","sequence":"additional","affiliation":[{"name":"Karolinska Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-4945","authenticated-orcid":false,"given":"Michael J.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"University of California San Diego"},{"name":"VA San Diego Healthcare System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"McElroy","sequence":"additional","affiliation":[{"name":"University of Cincinnati"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Colom","sequence":"additional","affiliation":[{"name":"Hospital del Mar Medical Research Institute (IMIM)-Hospital del Mar"},{"name":"Universitat de Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Millischer","sequence":"additional","affiliation":[{"name":"Karolinska Institute"},{"name":"Karolinska University Hospital"},{"name":"Medical University of Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Mitjans","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona"},{"name":"Esplugues de Llobregat"},{"name":"Carlos III Health Institute"},{"name":"Institut de Biomedicina de la Universit\u00e4t de Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis M.","family":"Mondimore","sequence":"additional","affiliation":[{"name":"Johns Hopkins University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palmiero","family":"Monteleone","sequence":"additional","affiliation":[{"name":"University of Campania \u2018Luigi Vanvitelli\u2019"},{"name":"University of Salerno"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Nievergelt","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus M.","family":"N\u00f6then","sequence":"additional","affiliation":[{"name":"University Hospital, Faculty of Medicine, University of Bonn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Novak","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"O\u2019Donovan","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Nagoya University Graduate School of Medicine Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pfennig","sequence":"additional","affiliation":[{"name":"TUD Dresden University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pisanu","sequence":"additional","affiliation":[{"name":"University of Cagliari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Potash","sequence":"additional","affiliation":[{"name":"Johns Hopkins University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Reif","sequence":"additional","affiliation":[{"name":"University Hospital Frankfurt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Reininghaus","sequence":"additional","affiliation":[{"name":"Medical University of Graz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy A.","family":"Rouleau","sequence":"additional","affiliation":[{"name":"McGill University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janus K.","family":"Rybakowski","sequence":"additional","affiliation":[{"name":"Poznan University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schalling","sequence":"additional","affiliation":[{"name":"Karolinska Institute"},{"name":"Karolinska University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Schofield","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia"},{"name":"University of New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara W.","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Johns Hopkins University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Severino","sequence":"additional","affiliation":[{"name":"University of Cagliari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Shilling","sequence":"additional","affiliation":[{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katzutaka","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Medical University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Simhandl","sequence":"additional","affiliation":[{"name":"Sigmund Freud University, Medical Faculty"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Slaney","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Squassina","sequence":"additional","affiliation":[{"name":"University of Cagliari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stamm","sequence":"additional","affiliation":[{"name":"Brandenburg Medical School"},{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavla","family":"Stopkova","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Maj","sequence":"additional","affiliation":[{"name":"University of Campania \u2018Luigi Vanvitelli\u2019"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Turecki","sequence":"additional","affiliation":[{"name":"McGill University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[{"name":"University of Barcelona, IDIBAPS, CIBERSAM"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Veeh","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Academy at the Gothenburg University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7317-1789","authenticated-orcid":false,"given":"Biju","family":"Viswanath","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neuro Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie H.","family":"Witt","sequence":"additional","affiliation":[{"name":"University of Heidelberg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Wright","sequence":"additional","affiliation":[{"name":"University of New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"Zandi","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip B.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"University of New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bauer","sequence":"additional","affiliation":[{"name":"TUD Dresden University of Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9544-3944","authenticated-orcid":false,"given":"Martin","family":"Alda","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health"},{"name":"Dalhousie University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Rietschel","sequence":"additional","affiliation":[{"name":"University of Heidelberg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis J.","family":"McMahon","sequence":"additional","affiliation":[{"name":"National Institutes of Health, United States Department of Health and Human Services"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Schulze","sequence":"additional","affiliation":[{"name":"University of Heidelberg"},{"name":"SUNY Upstate Medical University"},{"name":"National Institutes of Health, United States Department of Health and Human Services"},{"name":"Georg-August University G\u00f6ttingen"},{"name":"Johns Hopkins University"},{"name":"Partner site Munich-Augsburg"},{"name":"University Hospital, Ludwig Maximilian University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-426X","authenticated-orcid":false,"given":"Bernhard T.","family":"Baune","sequence":"additional","affiliation":[{"name":"University of M\u00fcnster"},{"name":"University of Melbourne"},{"name":"University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1690-0209","authenticated-orcid":false,"given":"K. Oliver","family":"Schubert","sequence":"additional","affiliation":[{"name":"Mental Health Services"},{"name":"Flinders University"},{"id":[{"id":"https:\/\/ror.org\/028g18b61","id-type":"ROR","asserted-by":"publisher"}],"name":"Adelaide University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7940-0335","authenticated-orcid":false,"given":"Azmeraw T.","family":"Amare","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/028g18b61","id-type":"ROR","asserted-by":"publisher"}],"name":"Adelaide University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"S0007125026107764_ref52","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00065"},{"key":"S0007125026107764_ref56","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-020-00191-4"},{"key":"S0007125026107764_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0689-5"},{"key":"S0007125026107764_ref7","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.2.217"},{"key":"S0007125026107764_ref29","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.261"},{"key":"S0007125026107764_ref57","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-020-00208-y"},{"key":"S0007125026107764_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00241-X"},{"key":"S0007125026107764_ref61","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050686"},{"key":"S0007125026107764_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415617657"},{"key":"S0007125026107764_ref30","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-02090-2"},{"key":"S0007125026107764_ref48","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13893"},{"key":"S0007125026107764_ref41","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-019-0138-9"},{"key":"S0007125026107764_ref6","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2001.00464.x"},{"key":"S0007125026107764_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02149-1"},{"key":"S0007125026107764_ref44","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocz228"},{"key":"S0007125026107764_ref13","first-page":"65","article-title":"Association of polygenic score for schizophrenia and HLA antigen and inflammation genes with response to lithium in bipolar affective disorder: a genome-wide association study","volume":"75","author":"Amare","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"S0007125026107764_ref33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09718-5"},{"key":"S0007125026107764_ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-024-00627-3"},{"key":"S0007125026107764_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/0004867416664794"},{"key":"S0007125026107764_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2023.08.016"},{"key":"S0007125026107764_ref23","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.163"},{"key":"S0007125026107764_ref51","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3736"},{"key":"S0007125026107764_ref4","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1949.tb36912.x"},{"key":"S0007125026107764_ref58","doi-asserted-by":"publisher","DOI":"10.1021\/cn5000309"},{"key":"S0007125026107764_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"S0007125026107764_ref46","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2022.28"},{"key":"S0007125026107764_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2019.04.002"},{"key":"S0007125026107764_ref60","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-016-0380-1"},{"key":"S0007125026107764_ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.11.063"},{"key":"S0007125026107764_ref62","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61842-0"},{"key":"S0007125026107764_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00143-4"},{"key":"S0007125026107764_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2025.02.005"},{"key":"S0007125026107764_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2022.136786"},{"key":"S0007125026107764_ref35","doi-asserted-by":"publisher","DOI":"10.1093\/bioadv\/vbad048"},{"key":"S0007125026107764_ref54","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00349"},{"key":"S0007125026107764_ref31","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-024-02865-4"},{"key":"S0007125026107764_ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065636"},{"key":"S0007125026107764_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13122"},{"key":"S0007125026107764_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2024.115817"},{"key":"S0007125026107764_ref38","doi-asserted-by":"publisher","DOI":"10.1145\/2939672.2939785"},{"key":"S0007125026107764_ref37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2005.00503.x"},{"key":"S0007125026107764_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2019.103413"},{"key":"S0007125026107764_ref28","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721000829"},{"key":"S0007125026107764_ref63","first-page":"100131","article-title":"Lithium for pain management and suicidality in spinal cord injury patients: a case report and review of the literature","volume":"2","author":"Reavis","year":"2023","journal-title":"Psychiatry Res Case Rep"},{"key":"S0007125026107764_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.046"},{"key":"S0007125026107764_ref27","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n1013"},{"key":"S0007125026107764_ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000314708"},{"key":"S0007125026107764_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad470"},{"key":"S0007125026107764_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsgos.2025.100558"},{"key":"S0007125026107764_ref22","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1038\/s41467-023-40330-w","article-title":"Multi-PGS enhances polygenic prediction by combining 937 polygenic scores","volume":"14","author":"Zhu","year":"2023","journal-title":"Nat Commun"},{"key":"S0007125026107764_ref36","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v033.i01"},{"key":"S0007125026107764_ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177657"},{"key":"S0007125026107764_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-020-1130-0"},{"key":"S0007125026107764_ref64","first-page":"211","article-title":"The individual and societal burden of treatment-resistant depression: an overview","volume":"46","author":"Baig-Ward","year":"2023","journal-title":"Psychiatr Clin"},{"key":"S0007125026107764_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01702-2"},{"key":"S0007125026107764_ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003348"},{"key":"S0007125026107764_ref39","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013203451"},{"key":"S0007125026107764_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-024-02998-6"},{"key":"S0007125026107764_ref24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-078378"},{"key":"S0007125026107764_ref40","doi-asserted-by":"publisher","DOI":"10.1186\/s40537-020-00349-y"},{"key":"S0007125026107764_ref42","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13048"},{"key":"S0007125026107764_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.02.002"},{"key":"S0007125026107764_ref34","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m441"},{"key":"S0007125026107764_ref65","doi-asserted-by":"publisher","DOI":"10.64898\/2026.01.01.25343187"},{"key":"S0007125026107764_ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000519707"}],"container-title":["The British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125026107764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:28:37Z","timestamp":1791365317000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125026107764\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":65,"alternative-id":["S0007125026107764"],"URL":"https:\/\/doi.org\/10.1192\/bjp.2026.10776","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of Royal College of Psychiatrists","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}