{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T23:16:07Z","timestamp":1761952567336,"version":"build-2065373602"},"reference-count":50,"publisher":"Royal College of Psychiatrists","issue":"407","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"unspecified","delay-in-days":24420,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. ment. sci"],"published-print":{"date-parts":[[1951,4]]},"abstract":"<jats:p>Since the introduction of penicillin into therapeutics the important question of the penetration of the blood-brain barrier by the antibiotic in infections of the nervous system has cropped up. In vital staining experiments Goldman (1913) observed that the acid semi-colloidal dye, trypan blue, which makes its way from the blood into the tissues, is unable to penetrate into the central nervous system. When the dye was injected into the cerebrospinal fluid it passed without difficulty into the brain substance. These observations were later verified by other investigators and have been verified for other substances (dyes, drugs, toxins, etc.).<\/jats:p>","DOI":"10.1192\/bjp.97.407.340","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T18:01:55Z","timestamp":1218045715000},"page":"340-361","source":"Crossref","is-referenced-by-count":7,"title":["Permeability of the Blood-Brain Barrier to Penicillin in Cases of Parenchymatous Neurosyphilis"],"prefix":"10.1192","volume":"97","author":[{"given":"Robert H. 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J."},{"key":"S0368315X0004411X_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF01945625"},{"key":"S0368315X0004411X_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1941.tb07398.x"},{"key":"S0368315X0004411X_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)77085-1"},{"key":"S0368315X0004411X_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1945.02860480018005"},{"key":"S0368315X0004411X_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1945.02860020024008"},{"key":"S0368315X0004411X_ref25","unstructured":"Moore J. E. (1944), The Modern Treatment of Syphilis, 2nd ed., p. 370."},{"key":"S0368315X0004411X_ref8","unstructured":"Dattner B. (1948), Med. Clin. North Amer., May, p. 707."},{"key":"S0368315X0004411X_ref9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101692"},{"key":"S0368315X0004411X_ref12","first-page":"434","volume":"ii","author":"Fleming","year":"1943","journal-title":"Ibid."},{"key":"S0368315X0004411X_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1945.02860210030007"},{"key":"S0368315X0004411X_ref14","first-page":"719","volume":"i","author":"Friedmann","year":"1934","journal-title":"Ibid."},{"key":"S0368315X0004411X_ref16","unstructured":"Goldman E. (1913), Vitalfarbung am Zentralnervensystem. Berlin."},{"key":"S0368315X0004411X_ref18","first-page":"622","volume":"124","author":"Herrell","year":"1944","journal-title":"Ibid."},{"key":"S0368315X0004411X_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-194706000-00003"},{"key":"S0368315X0004411X_ref30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101412"},{"key":"S0368315X0004411X_ref21","first-page":"317","volume":"31","author":"Kaplan","year":"1946","journal-title":"J. Lab. and Clin. Med."},{"key":"S0368315X0004411X_ref13","first-page":"621","volume":"ii","author":"Young","year":"1944","journal-title":"Ibid."},{"key":"S0368315X0004411X_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(45)91031-2"},{"key":"S0368315X0004411X_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1920.02180160002001"},{"key":"S0368315X0004411X_ref26","first-page":"403","volume":"29","author":"McDermott","year":"1945","journal-title":"Amer. J. 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