{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:46:10Z","timestamp":1780465570677,"version":"3.54.1"},"reference-count":15,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":4080,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J\n                        Psychiatry"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Klinefelter's syndrome, characterised by a 47, XXY chromosomal pattern, has\n                        largely been associated with physical abnormalities. Here, we report high\n                        levels of schizophrenia-spectrum pathology in 32 men with this syndrome in\n                        comparison with 26 healthy controls. This may have implications for\n                        treatment of Klinefelter's syndrome and suggests that the X chromosome may\n                        be involved in the aetiology of schizophrenia.<\/jats:p>","DOI":"10.1192\/bjp.bp.105.008961","type":"journal-article","created":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T10:36:14Z","timestamp":1162377374000},"page":"459-460","source":"Crossref","is-referenced-by-count":87,"title":["Klinefelter's syndrome (karyotype 47, XXY) and\n                        schizophrenia-spectrum pathology"],"prefix":"10.1192","volume":"189","author":[{"given":"Sophie","family":"van Rijn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Swaab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 S.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000232959_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(01)00350-4"},{"key":"S0007125000232959_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.08.018"},{"key":"S0007125000232959_ref10","volume-title":"Raven's Progressive Matrices and Vocabulary Scales","author":"Raven","year":"1988"},{"key":"S0007125000232959_ref9","volume-title":"National Adult Reading Test","author":"Nelson","year":"1982"},{"key":"S0007125000232959_ref8","first-page":"526","volume-title":"Organic Psychiatry: The Psychological Consequences of Cerebral Disorder","author":"Lishman","year":"1998"},{"key":"S0007125000232959_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16678-6"},{"key":"S0007125000232959_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00035-3"},{"key":"S0007125000232959_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.565"},{"key":"S0007125000232959_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30163"},{"key":"S0007125000232959_ref5","first-page":"257","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia.","volume":"18","author":"Kay","year":"1987","journal-title":"Schizophrenia Bulletin"},{"key":"S0007125000232959_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/20.3.495"},{"key":"S0007125000232959_ref2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.181.4.295"},{"key":"S0007125000232959_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(01)00353-X"},{"key":"S0007125000232959_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/20.1.191"},{"key":"S0007125000232959_ref13","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM\u2013IV and ICD\u201310.","volume":"59","author":"Sheehan","year":"1998","journal-title":"Journal of Clinical Psychiatry"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000232959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T15:40:37Z","timestamp":1556811637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000232959\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0007125000232959"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.105.008961","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}