{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:36:41Z","timestamp":1791117401268,"version":"4.1.0"},"reference-count":32,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":4111,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We have previously reported the Val66Met and GT(n) repeat polymorphisms of the brain-derived neurotrophic factor (BDNF) gene to be associated with bipolar disorder. However, these findings have not been replicated consistently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To dissect the association of the <jats:italic>BDNF<\/jats:italic> gene with bipolar disorder by examining additional markers at the DNA level and by testing the illness categories of bipolar disorder I and II and rapid cycling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a family-based association study and haplotype analyses with 312 nuclear families using four single nucleotide polymorphisms (SNPs) and the Val66Met and GT(n) repeat polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The SNPs hCVI1592756 and rs2049045, the Val66Met and GT(n) were significantly associated with bipolar disorder using transmission disequilibrium analyses (<jats:italic>P<\/jats:italic>=0.02, 0.009, 0.001 and 0.008 respectively). The effect at these markers was mainly driven by the rapid-cycling patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within bipolar disorder, variation in the <jats:italic>BDNF<\/jats:italic> gene appears to predict risk for developing rapid cycling according to DSM\u2013IV. Incorporating this clinical sub-phenotyping into other studies of the <jats:italic>BDNF<\/jats:italic> gene may help to resolve some of the inconsistencies reported thus far concerning BDNF and bipolar disorder.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.105.010587","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T21:40:04Z","timestamp":1163022004000},"page":"317-323","source":"Crossref","is-referenced-by-count":94,"title":["Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder"],"prefix":"10.1192","volume":"189","author":[{"given":"Daniel J.","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"De 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