{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:02:07Z","timestamp":1788670927877,"version":"build-2803163510"},"reference-count":37,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":4172,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J\n                        Psychiatry"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have examined the relative risks of switching into hypomania\n                           or mania associated with second-generation antidepressant drugs in\n                           bipolar depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the relative acute effects of bupropion, sertraline and\n                           venlafaxine as adjuncts to mood stabilisers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In a 10-week trial, participants receiving out-patient treatment for\n                           bipolar disorder (stratified for rapid cycling) were randomly treated\n                           with a flexible dose of one of the antidepressants, or their respective\n                           matching placebos, as adjuncts to mood stabilisers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 174 adults with bipolar disorder I, II or not otherwise\n                           specified, currently in the depressed phase, were included. All three\n                           antidepressants were associated with a similar range of acute response\n                           (49\u201353%) and remission (34\u201341%). There was a significantly increased risk\n                           of switches into hypomania or mania in participants treated with\n                           venlafaxine compared with bupropion or sertraline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More caution appears indicated in the use of venlafaxine rather than\n                           bupropion or sertraline in the adjunctive treatment of bipolar\n                           depression, especially if there is a prior history of rapid cycling.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.105.013045","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T14:58:07Z","timestamp":1236351487000},"page":"124-131","source":"Crossref","is-referenced-by-count":284,"title":["Mood switch in bipolar depression: comparison of adjunctive\n                        venlafaxine, bupropion and sertraline"],"prefix":"10.1192","volume":"189","author":[{"given":"R. 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