{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:18:34Z","timestamp":1791159514192,"version":"4.1.0"},"reference-count":38,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":3899,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Impulsive aggression in adulthood is associated with disturbances in serotonergic function. In contrast, research examining this association in childhood has yielded inconsistent results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The current study examined the prospective relationship between serotonergic function measured in childhood and the later emergence of antisocial personality disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Hormonal response to fenfluramine, an index of serotonergic function, was assessed in 58 children with attention-deficit hyperactivity disorder between 1990 and 1997 when they were aged 7\u201311 years. Approximately 9 years later these individuals were evaluated for antisocial personality disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower serotonergic responsivity assessed in childhood predicted the development of antisocial personality disorder (<jats:italic>t<\/jats:italic> (56)=2.25, <jats:italic>P<\/jats:italic>=0.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results provide a critical link between the child and adult literature on the covariation of impulsive aggression and serotonergic function and suggest a potential explanation for inconsistencies in the childhood literature.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.106.027847","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T19:23:40Z","timestamp":1177961020000},"page":"410-414","source":"Crossref","is-referenced-by-count":29,"title":["Serotonergic function in children with attention-deficit hyperactivity 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