{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:35:10Z","timestamp":1791027310774,"version":"4.1.0"},"reference-count":20,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":3594,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Two large, non-commercial clinical trials comparing first- and second-generation antipsychotic drugs for people with chronic schizophrenia in the US and UK have shown unexpected results. In general, the newer drugs were no more effective or better tolerated than the older drugs. Clozapine outperformed other second-generation drugs. The implications are considered.<\/jats:p>","DOI":"10.1192\/bjp.bp.107.037218","type":"journal-article","created":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T19:33:37Z","timestamp":1204313617000},"page":"161-163","source":"Crossref","is-referenced-by-count":111,"title":["CATIE and CUtLASS: can we handle the truth?"],"prefix":"10.1192","volume":"192","author":[{"given":"Sh\u00f4n","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000234132_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.553"},{"key":"S0007125000234132_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.6.633"},{"key":"S0007125000234132_ref4","article-title":"New generation antipsychotics vs low-potency conventional antipsychotics: a systematic review and meta-analysis","volume":"36","author":"Leucht","year":"2003","journal-title":"Lancet"},{"key":"S0007125000234132_ref19","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.8.1396"},{"key":"S0007125000234132_ref16","article-title":"Effectiveness and cost of olanzapine and haloperidol in the treatment of schizophrenia. A randomised controlled trial","volume":"29","author":"Rosenheck","year":"2003","journal-title":"JAMA"},{"key":"S0007125000234132_ref10","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.4.600"},{"key":"S0007125000234132_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7273.1371"},{"key":"S0007125000234132_ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051688"},{"key":"S0007125000234132_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.12.1624"},{"key":"S0007125000234132_ref13","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.12.2090"},{"key":"S0007125000234132_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.10.1079"},{"key":"S0007125000234132_ref14","unstructured":"Soares BG , Fenton F , Chue P . Sulpiride for schizophrenia Cochrane Library, issue 3. Update Software, 2002."},{"key":"S0007125000234132_ref18","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.106.028654"},{"key":"S0007125000234132_ref2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.2.176"},{"key":"S0007125000234132_ref17","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.12.2080"},{"key":"S0007125000234132_ref20","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.947"},{"key":"S0007125000234132_ref12","article-title":"Randomized controlled trial of effect of prescription of clozapine versus other second-generation antipsychotic drugs in resistant schizophrenia","volume":"32","author":"Lewis","year":"2006","journal-title":"Schizophr Bull"},{"key":"S0007125000234132_ref15","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.3.414"},{"key":"S0007125000234132_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800330013001"},{"key":"S0007125000234132_ref6","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.185"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000234132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T20:33:21Z","timestamp":1556656401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000234132\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0007125000234132"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.107.037218","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}