{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:07:37Z","timestamp":1790942857310,"version":"4.1.0"},"reference-count":30,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":3563,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J\n                        Psychiatry"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The role of folate, vitamin B<jats:sub>12<\/jats:sub> and homocysteine levels in\n                           depression is not clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate cross-sectional and prospective associations between\n                           folate, B<jats:sub>12<\/jats:sub> and homocysteine levels and late-life\n                           depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 732 Korean people aged 65 years or over were evaluated at\n                           baseline. Of the 631 persons who were not depressed, 521 (83%) were\n                           followed over a period of 2\u20133 years and incident depression was\n                           ascertained with the Geriatric Mental State schedule. Serum folate, serum\n                           vitamin B<jats:sub>12<\/jats:sub> and plasma homocysteine levels were assayed at\n                           both baseline and follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower levels of folate and vitamin B<jats:sub>12<\/jats:sub> and higher homocysteine\n                           levels at baseline were associated with a higher risk of incident\n                           depression at follow-up. Incident depression was associated with a\n                           decline in vitamin B<jats:sub>12<\/jats:sub> and an increase in homocysteine levels\n                           over the follow-up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lower folate, lower vitamin B<jats:sub>12<\/jats:sub> and raised homocysteine levels\n                           may be risk factors for late-life depression.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.107.039511","type":"journal-article","created":{"date-parts":[[2008,3,31]],"date-time":"2008-03-31T19:24:20Z","timestamp":1206991460000},"page":"268-274","source":"Crossref","is-referenced-by-count":213,"title":["Predictive value of folate, vitamin B<sub>12<\/sub> and\n                        homocysteine levels in late-life depression"],"prefix":"10.1192","volume":"192","author":[{"given":"Jae-Min","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Wan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il-Seon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Sang","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000234545_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001790"},{"key":"S0007125000234545_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700057779"},{"key":"S0007125000234545_ref6","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.185.2.102"},{"key":"S0007125000234545_ref4","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.12.2099"},{"key":"S0007125000234545_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.618"},{"key":"S0007125000234545_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.5.1158S"},{"key":"S0007125000234545_ref13","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.105.015032"},{"key":"S0007125000234545_ref12","first-page":"95","volume-title":"The 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