{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:46:18Z","timestamp":1789386378043,"version":"build-2803163510"},"reference-count":50,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":3410,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Eighteen patients with DSM\u2013IV trichotillomania and 19 healthy controls undertook structural magnetic resonance imaging after providing written informed consent. Differences in grey and white matter were investigated using computational morphometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with trichotillomania showed increased grey matter densities in the left striatum, left amygdalo-hippocampal formation, and multiple (including cingulate, supplementary motor, and frontal) cortical regions bilaterally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Trichotillomania was associated with structural grey matter changes in neural circuitry implicated in habit learning, cognition and affect regulation. These findings inform animal models of the disorder and highlight key regions of interest for future translational research.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.107.048314","type":"journal-article","created":{"date-parts":[[2008,8,31]],"date-time":"2008-08-31T19:12:48Z","timestamp":1220209968000},"page":"216-221","source":"Crossref","is-referenced-by-count":93,"title":["Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study"],"prefix":"10.1192","volume":"193","author":[{"given":"Samuel R.","family":"Chamberlain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara A.","family":"Menzies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi A.","family":"Fineberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"del Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Suckling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor W.","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward T.","family":"Bullmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Sahakian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000235903_ref15","doi-asserted-by":"publisher","DOI":"10.1109\/42.750253"},{"key":"S0007125000235903_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20027"},{"key":"S0007125000235903_ref5","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.4.568"},{"key":"S0007125000235903_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(93)90030-X"},{"key":"S0007125000235903_ref39","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5280.1399"},{"key":"S0007125000235903_ref28","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.179.4.330"},{"key":"S0007125000235903_ref43","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.7.1282"},{"key":"S0007125000235903_ref24","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"S0007125000235903_ref19","article-title":"The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability","volume":"46","author":"Goodman","year":"1989","journal-title":"Arch Gen Psychiatry"},{"key":"S0007125000235903_ref33","article-title":"Age-related changes in the pediatric brain: quantitative MR evidence of maturational changes during adolescence","volume":"18","author":"Steen","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"S0007125000235903_ref46","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144157"},{"key":"S0007125000235903_ref37","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1998.3843"},{"key":"S0007125000235903_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"S0007125000235903_ref20","volume-title":"National Adult Reading Test (NART): Test Manual","author":"Nelson","year":"1982"},{"key":"S0007125000235903_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12323-9"},{"key":"S0007125000235903_ref50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1547-5069.2003.00165.x"},{"key":"S0007125000235903_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.11.008"},{"key":"S0007125000235903_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00113-6"},{"key":"S0007125000235903_ref1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (4th edn, text revised) (DSM\u2013IV\u2013TR)","year":"2000"},{"key":"S0007125000235903_ref3","article-title":"Estimated lifetime prevalence of trichotillomania in college students","volume":"52","author":"Christenson","year":"1991","journal-title":"J Clin Psychiatry"},{"key":"S0007125000235903_ref4","first-page":"28","article-title":"Trichotillomania and obsessive-compulsive disorder","volume":"56","author":"Stein","year":"1995","journal-title":"J Clin Psychiatry"},{"key":"S0007125000235903_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(03)90012-X"},{"key":"S0007125000235903_ref2","article-title":"Clinical profile, comorbidity, and treatment history in 123 hair pullers: a survey study","volume":"56","author":"Cohen","year":"1995","journal-title":"J Clin Psychiatry"},{"key":"S0007125000235903_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nature06104"},{"key":"S0007125000235903_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.09.005"},{"key":"S0007125000235903_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm205"},{"key":"S0007125000235903_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00297-1"},{"key":"S0007125000235903_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.013"},{"key":"S0007125000235903_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.1997.tb03205.x"},{"key":"S0007125000235903_ref18","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"S0007125000235903_ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000289003"},{"key":"S0007125000235903_ref23","doi-asserted-by":"publisher","DOI":"10.1109\/42.906424"},{"key":"S0007125000235903_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"S0007125000235903_ref29","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.087148"},{"key":"S0007125000235903_ref30","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.5.950"},{"key":"S0007125000235903_ref31","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20765"},{"key":"S0007125000235903_ref32","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1994.00540210046012"},{"key":"S0007125000235903_ref35","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20273"},{"key":"S0007125000235903_ref36","doi-asserted-by":"publisher","DOI":"10.1038\/427311a"},{"key":"S0007125000235903_ref38","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.16-10-03444.1996","article-title":"Implementation of action sequences by a neostriatal site: a lesion mapping study of grooming syntax","volume":"16","author":"Cromwell","year":"1996","journal-title":"J Neurosci"},{"key":"S0007125000235903_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(00)26030-5"},{"key":"S0007125000235903_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6185(97)00024-8"},{"key":"S0007125000235903_ref45","doi-asserted-by":"crossref","DOI":"10.1097\/YCO.0b013e3280ba4989","article-title":"The neuropsychiatry of impulsivity","volume":"20","author":"Chamberlain","year":"2007","journal-title":"Curr Opin Psychiatry"},{"key":"S0007125000235903_ref47","article-title":"Characteristics of 60 adult chronic hair pullers","volume":"148","author":"Christenson","year":"1991","journal-title":"Am J Psychiatry"},{"key":"S0007125000235903_ref49","doi-asserted-by":"publisher","DOI":"10.1053\/comp.2001.23134"},{"key":"S0007125000235903_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00564-5"},{"key":"S0007125000235903_ref17","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM\u2013IV and ICD\u201310","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"S0007125000235903_ref34","doi-asserted-by":"publisher","DOI":"10.1038\/13158"},{"key":"S0007125000235903_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(97)00010-3"},{"key":"S0007125000235903_ref27","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000235903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T18:44:58Z","timestamp":1556649898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000235903\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0007125000235903"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.107.048314","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}