{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:34:56Z","timestamp":1791660896429,"version":"4.3.4"},"reference-count":43,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":2923,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although 5-hydroxytryptamine (5-HT) has been implicated in mania, the precise alterations in the 5-HT system remain elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess brain 5-HT<jats:sub>2<\/jats:sub>receptors in drug-free individuals experiencing a manic episode in comparison with healthy volunteers using positron emission tomography (PET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Participants (<jats:italic>n<\/jats:italic>= 10) with DSM\u2013IV bipolar I disorder \u2013 manic episode and healthy controls (<jats:italic>n<\/jats:italic>= 10) underwent [<jats:sup>18<\/jats:sup>F]- setoperone scans. The differences in 5-HT<jats:sub>2<\/jats:sub>receptor binding potential between the two groups were determined using statistical parametric mapping (SPM) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age was a significant correlate with 5-HT<jats:sub>2<\/jats:sub>receptor binding potential with a similar magnitude of correlation in both groups. The SPM analysis with age as a covariate showed that the individuals with current mania had significantly lower 5-HT<jats:sub>2<\/jats:sub>receptor binding potential in frontal, temporal, parietal and occipital cortical regions, with changes more prominent in the right cortical regions compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that brain 5-HT\u22172 receptors are decreased in people with acute mania.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.108.057919","type":"journal-article","created":{"date-parts":[[2009,12,31]],"date-time":"2009-12-31T23:52:54Z","timestamp":1262303574000},"page":"47-51","source":"Crossref","is-referenced-by-count":16,"title":["Brain serotonin-2 receptors in acute mania"],"prefix":"10.1192","volume":"196","author":[{"given":"Lakshmi N.","family":"Yatham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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