{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:47:22Z","timestamp":1767988042072,"version":"3.49.0"},"reference-count":17,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":2984,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We studied the course of major mood disorders in the offspring of parents with well-characterised bipolar disorder prospectively for up to 15 years. All consenting offspring were assessed annually or anytime symptomatic. The participants began to develop major mood episodes in adolescence and not before. The index major mood episode was almost always depressive, as were the first few recurrences. Onsets and recurrences continued throughout the observation period into adulthood. We did not find evidence of pre-pubertal mania. In summary, adolescence marks the beginning of the high-risk period for major mood episodes related to bipolar disorder.<\/jats:p>","DOI":"10.1192\/bjp.bp.108.062810","type":"journal-article","created":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:28:54Z","timestamp":1257035334000},"page":"457-458","source":"Crossref","is-referenced-by-count":100,"title":["Early course of bipolar disorder in high-risk offspring: prospective study"],"prefix":"10.1192","volume":"195","author":[{"given":"Anne","family":"Duffy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Alda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Hajek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Grof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000250988_ref17","doi-asserted-by":"crossref","DOI":"10.1192\/bjp.185.5.372","article-title":"Course of illness in depressive and bipolar disorders. Naturalistic study, 1994\u20131999","volume":"185","author":"Kessing","year":"2004","journal-title":"Br J Psychiatry"},{"key":"S0007125000250988_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00215.x"},{"key":"S0007125000250988_ref13","doi-asserted-by":"crossref","DOI":"10.31887\/DCNS.2008.10.2\/jangst","article-title":"Problems and perspectives in bipolar disorder","volume":"10","author":"Angst","year":"2008","journal-title":"Dialogues Clin Neurosci"},{"key":"S0007125000250988_ref12","first-page":"5","article-title":"Course of a clinical cohort of unipolar, bipolar and schizoaffective patients. Results of a prospective study from 1959 to 1985","volume":"146","author":"Angst","year":"1995","journal-title":"Schweizer Arch Neurol Psychiatri"},{"key":"S0007125000250988_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00359-2"},{"key":"S0007125000250988_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770310043002"},{"key":"S0007125000250988_ref8","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM\u2013IV)","year":"1994"},{"key":"S0007125000250988_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00421.x"},{"key":"S0007125000250988_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.10.1125"},{"key":"S0007125000250988_ref4","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.3.430"},{"key":"S0007125000250988_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.2.175"},{"key":"S0007125000250988_ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-0447.2003.00266.x"},{"key":"S0007125000250988_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.20013"},{"key":"S0007125000250988_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790330076009"},{"key":"S0007125000250988_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199707000-00021"},{"key":"S0007125000250988_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000177052.26476.e5"},{"key":"S0007125000250988_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S1121189X00006278"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000250988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T11:39:06Z","timestamp":1710675546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000250988\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0007125000250988"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.108.062810","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}