{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:45:46Z","timestamp":1791308746305,"version":"4.3.1"},"reference-count":45,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":2864,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J\n                        Psychiatry"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The epidemiology of rapid-cycling bipolar disorder in the community is\n                           largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the epidemiological characteristics of rapid-cycling and\n                           non-rapid-cycling bipolar disorder in a large cross-national community\n                           sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The Composite International Diagnostic Interview (CIDI version 3.0) was\n                           used to examine the prevalence, severity, comorbidity, impairment,\n                           suicidality, sociodemographics, childhood adversity and treatment of\n                           rapid-cycling and non-rapid-cycling bipolar disorder in ten countries\n                              (<jats:italic>n<\/jats:italic> = 54 257).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 12-month prevalence of rapid-cycling bipolar disorder was 0.3%.\n                           Roughly a third and two-fifths of participants with lifetime and 12-month\n                           bipolar disorder respectively met criteria for rapid cycling. Compared\n                           with the non-rapid-cycling, rapid-cycling bipolar disorder was associated\n                           with younger age at onset, higher persistence, more severe depressive\n                           symptoms, greater impairment from depressive symptoms, more out-of-role\n                           days from mania\/hypomania, more anxiety disorders and an increased\n                           likelihood of using health services. Associations regarding childhood,\n                           family and other sociodemographic correlates were less clear cut.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The community epidemiological profile of rapid-cycling bipolar disorder\n                           confirms most but not all current clinically based knowledge about the\n                           illness.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.109.067843","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T16:30:29Z","timestamp":1267461029000},"page":"217-225","source":"Crossref","is-referenced-by-count":50,"title":["Rapid-cycling bipolar disorder: cross-national community\n                        study"],"prefix":"10.1192","volume":"196","author":[{"given":"Sing","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adley","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie G.","family":"Karam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena Medina","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Merikangas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshibumi","family":"Nakane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Georgeta","family":"Popovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Posada-Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Sagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Elisabeth","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahari","family":"Zarkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Petukhova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000251891_ref24","doi-asserted-by":"crossref","unstructured":"Nierenberg AA , Akiskal HS , Angst J , Hirschfeld RM , Merikangas KR , Petukhova M , et al. Bipolar disorder with frequent mood episodes in the national comorbidity survey replication (NCS-R). Mol Psychiatry 2009; June 30 (Epub ahead of print).","DOI":"10.1038\/mp.2009.61"},{"key":"S0007125000251891_ref11","first-page":"91","volume-title":"The WHO World Mental Health Surveys: Global Perspectives on the Epidemiology of Mental Disorders","author":"Harkness","year":"2008"},{"key":"S0007125000251891_ref26","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900013900"},{"key":"S0007125000251891_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.06.003"},{"key":"S0007125000251891_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00560.x"},{"key":"S0007125000251891_ref43","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.186.2.121"},{"key":"S0007125000251891_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00113-X"},{"key":"S0007125000251891_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01239-2"},{"key":"S0007125000251891_ref32","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.9.1696"},{"key":"S0007125000251891_ref33","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.3.261"},{"key":"S0007125000251891_ref37","first-page":"1","article-title":"Practice guideline for the treatment of patients with bipolar disorder (revision)","volume":"159","year":"2002","journal-title":"Am J Psychiatry"},{"key":"S0007125000251891_ref30","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.161.10.1902"},{"key":"S0007125000251891_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00558.x"},{"key":"S0007125000251891_ref28","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n1213"},{"key":"S0007125000251891_ref25","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.037820"},{"key":"S0007125000251891_ref8","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.05081484"},{"key":"S0007125000251891_ref35","article-title":"Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys","volume":"291","author":"Demyttenaere","year":"2004","journal-title":"JAMA"},{"key":"S0007125000251891_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.10.017"},{"key":"S0007125000251891_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1974.01760080077013"},{"key":"S0007125000251891_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00557.x"},{"key":"S0007125000251891_ref2","article-title":"Multisite data reanalysis of the validity of rapid cycling as a course modifier for bipolar disorder in DSM\u2013IV","volume":"151","author":"Bauer","year":"1994","journal-title":"Am J Psychiatry"},{"key":"S0007125000251891_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00156.x"},{"key":"S0007125000251891_ref7","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1266"},{"key":"S0007125000251891_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.168"},{"key":"S0007125000251891_ref10","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (4th edn, revised) (DSM\u2013IV\u2013TR)","year":"2000"},{"key":"S0007125000251891_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.08.018"},{"key":"S0007125000251891_ref13","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"S0007125000251891_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01866-8"},{"key":"S0007125000251891_ref15","doi-asserted-by":"publisher","DOI":"10.2190\/T8EM-C8YH-373N-1UWD"},{"key":"S0007125000251891_ref16","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders (Research Version, Non-patient Edition SCID-I\/NP)","author":"First","year":"2002"},{"key":"S0007125000251891_ref17","article-title":"Clinical calibration of DSM-IV diagnoses in the World Mental Health (WMH) version of the World Health Organization (WHO) Composite International Diagnostic Interview (WMH-CIDI)","volume":"13","author":"Kessler","year":"2004","journal-title":"Int J Methods Psychiatr Res"},{"key":"S0007125000251891_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.196"},{"key":"S0007125000251891_ref19","volume-title":"The WHO World Mental Health Surveys: Global Perspectives on the Epidemiology of Mental Disorders","author":"Haro","year":"2008"},{"key":"S0007125000251891_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.12.1322"},{"key":"S0007125000251891_ref29","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.9.914"},{"key":"S0007125000251891_ref31","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.217"},{"key":"S0007125000251891_ref34","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.6.530"},{"key":"S0007125000251891_ref38","doi-asserted-by":"publisher","DOI":"10.1177\/002214650804900306"},{"key":"S0007125000251891_ref39","doi-asserted-by":"publisher","DOI":"10.2307\/2136367"},{"key":"S0007125000251891_ref40","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.10.1434"},{"key":"S0007125000251891_ref41","volume-title":"Bipolar Disorder","author":"Shulman","year":"2002"},{"key":"S0007125000251891_ref44","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579401003091"},{"key":"S0007125000251891_ref45","volume-title":"The ICD\u201310 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines","year":"1992"},{"key":"S0007125000251891_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2007.12.004"},{"key":"S0007125000251891_ref5","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1273"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000251891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T20:44:28Z","timestamp":1556484268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000251891\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0007125000251891"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.109.067843","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}