{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:52:02Z","timestamp":1768290722073,"version":"3.49.0"},"reference-count":34,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":2833,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J\n                        Psychiatry"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Many people suffer from subthreshold and mild panic disorder and are at\n                           risk of developing more severe panic disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study (trial registration: ISRCTN33407455) was conducted to evaluate\n                           the effectiveness of an early group intervention based on\n                           cognitive\u2013behavioural principles to reduce panic disorder\n                           symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Participants with subthreshold or mild panic disorder were recruited from\n                           the general population and randomised to the intervention\n                              (<jats:italic>n<\/jats:italic> = 109) or a waiting-list control group\n                              (<jats:italic>n<\/jats:italic> = 108). The course was offered by 17 community\n                           mental health centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the early intervention group, 43\/109 (39%) participants presented with\n                           a clinically significant change on the Panic Disorder Severity Scale\u2013Self\n                           Report (PDSS\u2013SR) <jats:italic>v.<\/jats:italic> 17\/108 (16%) in the control group\n                           (odds ratio (OR) for favourable treatment response 3.49, 95% CI\n                           1.77\u20136.88, <jats:italic>P<\/jats:italic> = 0.001). The course also had a positive\n                           effect on DSM\u2013IV panic disorder status (OR = 1.96, 95% CI=1.05\u20133.66,\n                              <jats:italic>P<\/jats:italic> = 0.037). The PDSS\u2013SR symptom reduction was also\n                           substantial (between-group standardised mean difference of 0.68). The\n                           effects were maintained at 6-month follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>People presenting with subthreshold and mild panic disorder benefit from\n                           this brief intervention.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.109.072504","type":"journal-article","created":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T22:25:49Z","timestamp":1270074349000},"page":"326-331","source":"Crossref","is-referenced-by-count":29,"title":["Early intervention in panic: pragmatic randomised controlled\n                        trial"],"prefix":"10.1192","volume":"196","author":[{"given":"Peter","family":"Meulenbeek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godelief","family":"Willemse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Smit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"van Balkom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Spinhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim","family":"Cuijpers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000252276_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(92)90110-T"},{"key":"S0007125000252276_ref7","article-title":"Brief treatment of emergency room patients with panic attacks","volume":"149","author":"Swinson","year":"1992","journal-title":"Am J Psychiatry"},{"key":"S0007125000252276_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(85)90140-8"},{"key":"S0007125000252276_ref26","volume-title":"Manual for the Beck Depression Inventory-II","author":"Beck","year":"1996"},{"key":"S0007125000252276_ref28","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.59.1.12"},{"key":"S0007125000252276_ref10","volume-title":"M.I.N.I. 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