{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:40:08Z","timestamp":1788990008863,"version":"build-2803163510"},"reference-count":43,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":2041,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J\n                        Psychiatry"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Visual hallucinations and visuoperceptual deficits are common in dementia\n                           with Lewy bodies, suggesting that cortical visual function may be\n                           abnormal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate: (1) cortical visual function using functional magnetic\n                           resonance imaging (fMRI); and (2) the nature and severity of perfusion\n                           deficits in visual areas using arterial spin labelling (ASL)-MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In total, 17 participants with dementia with Lewy bodies (DLB group) and\n                           19 similarly aged controls were presented with simple visual stimuli\n                           (checkerboard, moving dots, and objects) during fMRI and subsequently\n                           underwent ASL-MRI (DLB group <jats:italic>n<\/jats:italic> = 15, control group\n                              <jats:italic>n<\/jats:italic> = 19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Functional activations were evident in visual areas in both the DLB and\n                           control groups in response to checkerboard and objects stimuli but\n                           reduced visual area V5\/MT (middle temporal) activation occurred in the\n                           DLB group in response to motion stimuli. Posterior cortical perfusion\n                           deficits occurred in the DLB group, particularly in higher visual\n                           areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher visual areas, particularly occipito-parietal, appear abnormal in\n                           dementia with Lewy bodies, while there is a preservation of function in\n                           lower visual areas (V1 and V2\/3).<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.111.099432","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T21:32:38Z","timestamp":1334266358000},"page":"491-498","source":"Crossref","is-referenced-by-count":78,"title":["Visual cortex in dementia with Lewy bodies: Magnetic resonance\n                        imaging study"],"prefix":"10.1192","volume":"200","author":[{"given":"John-Paul","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Firbank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthea","family":"Livingstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quoc","family":"Vuong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian G.","family":"McKeith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000079563_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.05.012"},{"key":"S0007125000079563_ref34","doi-asserted-by":"publisher","DOI":"10.1159\/000051257"},{"key":"S0007125000079563_ref15","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.177.3.252"},{"key":"S0007125000079563_ref38","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.12.2229"},{"key":"S0007125000079563_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0919-x"},{"key":"S0007125000079563_ref14","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000145764.70698.4E"},{"key":"S0007125000079563_ref42","article-title":"Brain perfusion correlates of visuoperceptual deficits in mild cognitive impairment and mild Alzheimer's disease","volume":"21","author":"Alegret","year":"2010","journal-title":"J Alzheimer's Dis"},{"key":"S0007125000079563_ref30","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.6.1284"},{"key":"S0007125000079563_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.9.911"},{"key":"S0007125000079563_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/3.2.79"},{"key":"S0007125000079563_ref43","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000203114.03976.b0"},{"key":"S0007125000079563_ref27","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000269666.62598.1c"},{"key":"S0007125000079563_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.389"},{"key":"S0007125000079563_ref13","volume-title":"Recent Developments in Parkinson's Disease","author":"Fahn","year":"1987"},{"key":"S0007125000079563_ref37","article-title":"Nicotinic [alpha]4[beta]2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations","volume":"40","author":"O'Brien","year":"2008","journal-title":"NeuroImage"},{"key":"S0007125000079563_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22258"},{"key":"S0007125000079563_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e328155d143"},{"key":"S0007125000079563_ref4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.5.643"},{"key":"S0007125000079563_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199906230-00020"},{"key":"S0007125000079563_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl102"},{"key":"S0007125000079563_ref7","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000141853.27081.BD"},{"key":"S0007125000079563_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp223"},{"key":"S0007125000079563_ref12","article-title":"Mini-Mental State. 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