{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:47:31Z","timestamp":1791546451418,"version":"4.3.4"},"reference-count":46,"publisher":"Royal College of Psychiatrists","issue":"3","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":1768,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about whether treatment in a specialised out-patient mood disorder clinic improves long-term prognosis for patients discharged from initial psychiatric hospital admissions for bipolar disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To assess the effect of treatment in a specialised out-patient mood disorder clinic\n                      <jats:italic>v.<\/jats:italic>\n                      standard decentralised psychiatric treatment among patients discharged from one of their first three psychiatric hospital admissions for bipolar disorder.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients discharged from their first, second or third hospital admission with a single manic episode or bipolar disorder were randomised to treatment in a specialised out-patient mood disorder clinic or standard care (ClinicalTrials.gov: NCT00253071). The primary outcome measure was readmission to hospital, which was obtained from the Danish Psychiatric Central Register.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 158 patients with mania\/bipolar disorder were included. The rate of readmission to hospital was significantly decreased for patients treated in the mood disorder clinic compared with standard treatment (unadjusted hazard ratio 0.60, 95% CI 0.37\u20130.97,\n                      <jats:italic>P<\/jats:italic>\n                      =0.034). Patients treated in the mood disorder clinic more often used a mood stabiliser or an antipsychotic and satisfaction with treatment was more prevalent than among patients who received standard care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment in a specialised mood disorder clinic early in the course of bipolar disorder substantially reduces readmission to a psychiatric hospital and increases satisfaction with care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.bp.112.113548","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T21:20:21Z","timestamp":1359062421000},"page":"212-219","source":"Crossref","is-referenced-by-count":206,"title":["Treatment in a specialised out-patient mood disorder clinic\n                    <i>v.<\/i>\n                    standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial"],"prefix":"10.1192","volume":"202","author":[{"given":"Lars Vedel","family":"Kessing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Vibe","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Hvenegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Margrethe","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Dam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gluud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Wetterslev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Early Intervention Affective Disorders (EIA) Trial Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000273856_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00405.x"},{"key":"S0007125000273856_ref37","volume-title":"Cause of Death in Denmark","year":"1992"},{"key":"S0007125000273856_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145707007821"},{"key":"S0007125000273856_ref6","article-title":"Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial","volume":"375","author":"Geddes","year":"2010","journal-title":"Lancet"},{"key":"S0007125000273856_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.4.402"},{"key":"S0007125000273856_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/j.2051-5545.2011.tb00037.x"},{"key":"S0007125000273856_ref33","volume-title":"Preventive Outpatient Treatment in Affective Disorders. 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