{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:56:26Z","timestamp":1791860186724,"version":"4.3.4"},"reference-count":45,"publisher":"Royal College of Psychiatrists","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":732,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J\n                        Psychiatry"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Adjunctive antidepressant therapy is commonly used to treat acute bipolar\n                           depression but few studies have examined this strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the efficacy of agomelatine <jats:italic>v.<\/jats:italic> placebo as\n                           adjuncts to lithium or valproate in bipolar depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients who were currently depressed despite taking lithium or valproate\n                           for at least 6 weeks were randomised to treatment with agomelatine\n                              (<jats:italic>n<\/jats:italic> = 172) or placebo (<jats:italic>n<\/jats:italic> = 172) for 8\n                           weeks of acute therapy and 44 weeks of continuation therapy (trial\n                           registration: ISRCTN28588282).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in improvement of depressive symptoms were\n                           observed between the two groups either at 8 weeks or 52 weeks on the\n                           primary efficacy measure of change in Montgomery\u2013\u00c5sberg Depression Rating\n                           Scale scores from baseline to end-point. Adverse events including\n                           switches into mania\/hypomania were low and similar in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Agomelatine adjunctive therapy was not superior to placebo adjunctive\n                           therapy for acute bipolar depression.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.114.147587","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T20:30:52Z","timestamp":1432240252000},"page":"78-86","source":"Crossref","is-referenced-by-count":73,"title":["Agomelatine or placebo as adjunctive therapy to a mood\n                        stabiliser in bipolar I depression: Randomised double-blind\n                        placebo-controlled trial"],"prefix":"10.1192","volume":"208","author":[{"given":"Lakshmi 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