{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:41:57Z","timestamp":1790534517994,"version":"4.1.0"},"reference-count":14,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":977,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A single-nucleotide polymorphism (SNP) of the <jats:italic>DRD3<\/jats:italic> gene (rs167771) was recently associated with autism spectrum disorders (ASD). Different polymorphisms of rs167771 corresponded to varying degrees of stereotyped behaviour. As DRD3 receptors are relatively overexpressed in the striatum, we investigated whether striatal volume was related to these polymorphisms in autism. We assessed volumes of caudate nucleus and putamen in 86 participants with ASD (mean age 15.3 years). MANCOVA showed an association between alleles of the rs167771 SNP and the volume of striatal structures. Furthermore, greater caudate nucleus volume correlated with stereotyped behaviour. These findings support a relationship between <jats:italic>DRD3<\/jats:italic> gene SNPs, striatum and stereotyped behaviour in ASD.<\/jats:p>","DOI":"10.1192\/bjp.bp.114.148973","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T17:08:02Z","timestamp":1426871282000},"page":"431-432","source":"Crossref","is-referenced-by-count":33,"title":["<i>DRD3<\/i> gene and striatum in autism spectrum disorder"],"prefix":"10.1192","volume":"206","author":[{"given":"Wouter G.","family":"Staal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Langen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarai","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent T.","family":"Mensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Durston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000238312_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-011-9500-3"},{"key":"S0007125000238312_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.03.033"},{"key":"S0007125000238312_ref11","article-title":"The Autism Diagnostic Observation Schedule \u2013 generic: a standard measure of social and communication deficits associated with the spectrum of autism","volume":"30","author":"Lord","year":"2000","journal-title":"J Autism Dev Disord"},{"key":"S0007125000238312_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172145"},{"key":"S0007125000238312_ref6","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.602719"},{"key":"S0007125000238312_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.09.035"},{"key":"S0007125000238312_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.08.013"},{"key":"S0007125000238312_ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-6-56"},{"key":"S0007125000238312_ref1","article-title":"The neurobiology of repetitive behavior: \u2026 and men","volume":"35","author":"Langen","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"S0007125000238312_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.03.017"},{"key":"S0007125000238312_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-011-1312-z"},{"key":"S0007125000238312_ref13","doi-asserted-by":"publisher","DOI":"10.1586\/ern.12.145"},{"key":"S0007125000238312_ref9","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (4th edn, text revision) (DSM-IV-TR).","year":"2000"},{"key":"S0007125000238312_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2009.26"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000238312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T01:38:15Z","timestamp":1555810695000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000238312\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0007125000238312"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.114.148973","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}