{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:40:32Z","timestamp":1761597632373},"reference-count":40,"publisher":"Royal College of Psychiatrists","issue":"5","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":793,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J\n                        Psychiatry"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The contribution of education and intelligence to resilience against\n                           age-related cognitive decline is not clear, particularly in the presence\n                           of \u2018normal for age\u2019 minor brain abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Participants (<jats:italic>n<\/jats:italic> = 208, mean age 69.2 years, s.d. = 5.4)\n                           in the Whitehall II imaging substudy attended for neuropsychological\n                           testing and multisequence 3T brain magnetic resonance imaging. Images\n                           were independently rated by three trained clinicians for global and\n                           hippocampal atrophy, periventricular and deep white matter changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although none of the participants qualified for a clinical diagnosis of\n                           dementia, a screen for cognitive impairment (Montreal Cognitive\n                           Assessment (MoCA) &lt;26) was abnormal in 22%. Hippocampal atrophy, in\n                           contrast to other brain measures, was associated with a reduced MoCA\n                           score even after controlling for age, gender, socioeconomic status, years\n                           of education and premorbid IQ. Premorbid IQ and socioeconomic status were\n                           associated with resilience in the presence of hippocampal atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Independent contributions from <jats:italic>a priori<\/jats:italic> risk (age,\n                           hippocampal atrophy) and resilience (premorbid function, socioeconomic\n                           status) combine to predict measured cognitive impairment.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.114.152363","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:43:20Z","timestamp":1441327400000},"page":"435-439","source":"Crossref","is-referenced-by-count":8,"title":["Resilience and MRI correlates of cognitive impairment in\n                        community-dwelling 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