{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T11:56:02Z","timestamp":1782647762208,"version":"3.54.5"},"reference-count":35,"publisher":"Royal College of Psychiatrists","issue":"4","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":641,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Management of long-term depression is a significant problem in primary care populations with considerable on-going morbidity, but few studies have focused on this group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate whether structured, nurse-led proactive care of patients with chronic depression in primary care improves outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Participants with chronic\/recurrent major depression or dysthymia were recruited from 42 UK general practices and randomised to general practitioner (GP) treatment as usual or nurse intervention over 2 years (the ProCEED trial, trial registration: ISRCTN36610074).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total 282 people received the intervention and there were 276 controls. At 24 months there was no significant improvement in Beck Depression Inventory (BDI-II) score or quality of life (Euroquol-EQ-VAS), but a significant improvement in functional impairment (Work and Social Activity Schedule, WSAS) of 2.5 (95% CI 0.6\u20134.3, <jats:italic>P<\/jats:italic> = 0.010) in the intervention group. The impact per practice-nurse intervention session was \u20130.37 (95% CI \u20130.68 to \u20130.07, <jats:italic>P<\/jats:italic> = 0.017) on the BDI-II score and \u20130.33 (95% CI \u20130.55 to \u20130.10, <jats:italic>P<\/jats:italic> = 0.004) on the WSAS score, indicating that attending all 10 intervention sessions could lead to a BDI-II score reduction of 3.7 points compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The intervention improved functioning in these patients, the majority of whom had complex long-term difficulties, but only had a significant impact on depressive symptoms in those engaging with the full intervention.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.114.153312","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T01:44:02Z","timestamp":1453427042000},"page":"374-380","source":"Crossref","is-referenced-by-count":11,"title":["Practice nurse-led proactive care for chronic depression in primary care: A randomised controlled trial"],"prefix":"10.1192","volume":"208","author":[{"given":"Marta","family":"Buszewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine M.","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Walters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000240920_ref35","volume-title":"ProCEED. 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