{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:22:32Z","timestamp":1790306552954,"version":"4.1.0"},"reference-count":42,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":701,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J\n                        Psychiatry"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Delusional disorder has been the subject of very little investigation\n                           using brain imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine potential structural and\/or functional brain abnormalities in\n                           this disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      We used structural imaging (voxel-based morphometry, VBM) and functional\n                           imaging (during performance of the\n                      <jats:italic>n<\/jats:italic>\n                      -back task and\n                           whole-brain resting connectivity analysis) to examine 22 patients meeting\n                           DSM-IV criteria for delusional disorder and 44 matched healthy\n                           controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients showed grey matter reductions in the medial frontal\/anterior\n                           cingulate cortex and bilateral insula on unmodulated (but not on\n                           modulated) VBM analysis, failure of de-activation in the medial\n                           frontal\/anterior cingulate cortex during performance of the\n                      <jats:italic>n<\/jats:italic>\n                      -back task, and decreased resting-state connectivity\n                           in the bilateral insula.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings provide evidence of brain abnormality in the medial\n                           frontal\/anterior cingulate cortex and insula in delusional disorder. A\n                           role for the former region in the pathogenesis of delusions is consistent\n                           with several other lines of evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1192\/bjp.bp.114.159087","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T04:25:22Z","timestamp":1442550322000},"page":"153-159","source":"Crossref","is-referenced-by-count":36,"title":["Structural and functional brain changes in delusional\n                        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