{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:12:24Z","timestamp":1781478744700,"version":"3.54.1"},"reference-count":13,"publisher":"Royal College of Psychiatrists","issue":"2","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":701,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Several genome-wide association studies and case\u2013control studies have associated the single nucleotide polymorphism (SNP) rs1006737, situated in<jats:italic>CACNA1C<\/jats:italic>encoding the alpha 1C subunit of the L-type voltage-gated calcium channel, with bipolar disorder and other psychiatric disorders. However, the causal pathway linking genetic variants in<jats:italic>CACNA1C<\/jats:italic>with increased risk for developing brain disorders remains unclear. Here, we explored the association between the rs1006737 SNP and cerebrospinal fluid (CSF) markers. We found a significant association between the risk allele in rs1006737 and a decreased CSF hyperphosphorylated tau\/total tau ratio in patients with bipolar disorder, thus linking variation in the<jats:italic>CACNA1C<\/jats:italic>gene to a neurochemical marker of neuroaxonal plasticity in those with this disorder.<\/jats:p>","DOI":"10.1192\/bjp.bp.114.159806","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T02:19:27Z","timestamp":1446776367000},"page":"195-196","source":"Crossref","is-referenced-by-count":20,"title":["<i>CACNA1C<\/i>polymorphism and altered phosphorylation of tau in bipolar disorder"],"prefix":"10.1192","volume":"208","author":[{"given":"Joel","family":"Jakobsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"P\u00e5lsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Sellgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida","family":"Rydberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Ekman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Land\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000240671_ref13","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.4"},{"key":"S0007125000240671_ref12","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2003"},{"key":"S0007125000240671_ref11","doi-asserted-by":"crossref","first-page":"re15","DOI":"10.1126\/stke.3152005re15","article-title":"Regulation of voltage-gated Ca2+ channels by calmodulin","volume":"2005","author":"Halling","year":"2005","journal-title":"Sci STKE"},{"key":"S0007125000240671_ref10","volume-title":"ECDEU Assessment Manual for Psychopharmacology. Revised DHEW Pub. (ADM).","author":"Guy","year":"1976"},{"key":"S0007125000240671_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00165-3"},{"key":"S0007125000240671_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.81"},{"key":"S0007125000240671_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.06.001"},{"key":"S0007125000240671_ref2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003947"},{"key":"S0007125000240671_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60855-7"},{"key":"S0007125000240671_ref9","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.166.5.654"},{"key":"S0007125000240671_ref5","article-title":"Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis","volume":"381","author":"Smoller","year":"2013","journal-title":"Lancet"},{"key":"S0007125000240671_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.96"},{"key":"S0007125000240671_ref7","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.231"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000240671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T12:02:53Z","timestamp":1653480173000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000240671\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0007125000240671"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.114.159806","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}