{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:28:57Z","timestamp":1790101737391,"version":"4.0.1"},"reference-count":30,"publisher":"Royal College of Psychiatrists","issue":"6","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"unspecified","delay-in-days":580,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Psychiatry"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Gambling disorder is a relatively common psychiatric disorder recently re-classified within the DSM-5 under the category of \u2018substance-related and addictive disorders'.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare white matter integrity in patients with gambling disorder with healthy controls; to explore relationships between white matter integrity and disease severity in gambling disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In total, 16 participants with treatment-resistant gambling disorder and 15 healthy controls underwent magnetic resonance imaging (MRI). White matter integrity was analysed using tract-based spatial statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gambling disorder was associated with reduced fractional anisotropy in the corpus callosum and superior longitudinal fasciculus. Fractional anisotropy in distributed white matter tracts elsewhere correlated positively with disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reduced corpus callosum fractional anisotropy is suggestive of disorganised\/damaged tracts in patients with gambling disorder, and this may represent a trait\/vulnerability marker for the disorder. Future research should explore these measures in a larger sample, ideally incorporating a range of imaging markers (for example functional MRI) and enrolling unaffected first-degree relatives of patients.<\/jats:p><\/jats:sec>","DOI":"10.1192\/bjp.bp.115.165506","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T20:53:14Z","timestamp":1454619194000},"page":"579-584","source":"Crossref","is-referenced-by-count":10,"title":["White matter tract integrity in treatment-resistant gambling disorder"],"prefix":"10.1192","volume":"208","author":[{"given":"Samuel R.","family":"Chamberlain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Derbyshire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Daws","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Odlaug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric W.","family":"Leppink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon E.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"170","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"S0007125000244085_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.081"},{"key":"S0007125000244085_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2014.11.020"},{"key":"S0007125000244085_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.008"},{"key":"S0007125000244085_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01079-4"},{"key":"S0007125000244085_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62185-X"},{"key":"S0007125000244085_ref7","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200422060-00003"},{"key":"S0007125000244085_ref18","volume-title":"The Anxiety Disease","author":"Sheehan","year":"1983"},{"key":"S0007125000244085_ref8","volume-title":"Diagnostic and\n                           Statistical Manual of Mental Disorders (5th edn) (DSM-5)","year":"2013"},{"key":"S0007125000244085_ref16","first-page":"22","article-title":"The Mini-International Neuropsychiatric\n                           Interview (M.I.N.I.): the development and validation of a structured\n                           diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"S0007125000244085_ref28","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20102"},{"key":"S0007125000244085_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2006.03.003"},{"key":"S0007125000244085_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"S0007125000244085_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2014.01.012"},{"key":"S0007125000244085_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.08.001"},{"key":"S0007125000244085_ref17","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"S0007125000244085_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.03.006"},{"key":"S0007125000244085_ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00141"},{"key":"S0007125000244085_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2012.07.001"},{"key":"S0007125000244085_ref19","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.4.1.92"},{"key":"S0007125000244085_ref3","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v62n1207"},{"key":"S0007125000244085_ref6","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.568068"},{"key":"S0007125000244085_ref9","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.062414"},{"key":"S0007125000244085_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1235-3"},{"key":"S0007125000244085_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10899-005-5557-3"},{"key":"S0007125000244085_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2004.05.006"},{"key":"S0007125000244085_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S1352465809990701"},{"key":"S0007125000244085_ref15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.psychres.2007.11.008","article-title":"The Gambling Symptom Assessment Scale (G-SAS): a\n                           reliability and validity study","volume":"166","author":"Kim","year":"2009","journal-title":"Psychiatry\n                           Res"},{"key":"S0007125000244085_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"S0007125000244085_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.109"},{"key":"S0007125000244085_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.08.004"}],"container-title":["British Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007125000244085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:16:58Z","timestamp":1555633018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007125000244085\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0007125000244085"],"URL":"https:\/\/doi.org\/10.1192\/bjp.bp.115.165506","relation":{},"ISSN":["0007-1250","1472-1465"],"issn-type":[{"value":"0007-1250","type":"print"},{"value":"1472-1465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}